Off‐label trazodone prescription: evidence, benefits and risks. Curr Pharm Des. 2015;21(23):3343‐3351.Off-Label Trazodone Prescription: Evidence, Benefits and Risks[J] . Letizia Bossini,Anna Coluccia,Ilaria Casolaro,Jim Benbow,Giovanni Amodeo,Riccardo De Giorgi,Andrea Fagiolini.Current ...
SAMe has been studied for the treatment of depressive disorders. It has been shown to be equivalent to tricyclics, and there is a paucity of comparative data versus newer agents. Information regarding its use in osteoarthritis is conflicting and information regarding its use in liver disorders and...
Ramelteon, a novel agent with high selectivity for melatonin receptors, has recently been approved in the US. Use of the antidepressant trazodone for sleep in nondepressed patients is somewhat controversial. Atypical antipsychotics should not be used to treat insomnia unless there is also evidence of...
Of all the 5-HT2A antagonists, trazodone is perhaps most commonly combined with the SSRIs both as an adjunctive agent and a possible augmentor. Currently, the most common reason for adding trazodone to an SSRI is to improve sleep. In a double-blind study, 15 patients with insomnia on fluox...
It has been used in Japan for insomnia, screaming attacks, sleep terrors, neurosis, irritability in children, borderline personality disorder, schizophrenia-related diseases, and behavioral and psychological symptoms of dementia. Increasingly, beneficial effects in psychiatric disorders, including schizophrenia...
In animal studies, pretreatment of the skin with several essential oils increased the flux values of trazodone. Pretreatment with a solution containing 10% fennel oil in propylene glycol showed an enhancement ratio of 9.25 compared with the control. The incorporation of fennel in the transdermal devi...
More recent meta-analyses examining the benefits and risks of St. John's wort compared to selective serotonin reuptake inhibitors (SSRIs), specifically in patients with major depressive disorder (MDD), found no statistically significant difference in response, remission, and depression scores between ...