Because famotidine is primarily excreted by the kidneys, dosing depends on the maturity of the renal function. Infants younger than 3 months of age have reduced clearance and require 24 hours between doses (0.25 mg/kg IV or 0.5 mg/kg orally), whereas infants older than 3 months are...
a greater effect on the maintenance of sleep than on sleep initiation was also noted with doxepin when dosed in a range where it is a highly selective H1antagonist. In a study examining the sedating effects associated with daytime dosing of diphenhydramine, a sedating effect seen on the first...