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敏感性的人乳腺癌细胞MCF-7和不依赖甾类的Hela细胞作为研究对象,研究发现异甘草素的抗增殖作用有双向性:在低中浓度下,其有转录活性,可刺激MCF-7细胞的增殖;然而,高浓度的异甘草素有细胞毒性,即使对甾体激素受体不敏感的Hela细胞,其作用也很明显,而这与异甘草素下调雌激素受体α蛋白的表达和上调pS2mRNA的含量是...