Bempedoic acid (Nilemdo) is a new lipid﹍owering therapy for the treatment of primary hypercholesterolaemia and mixed dyslipidaemia. This article summarises its mechanism of action, clinical trial efficacy and side〆ffects.doi:10.1002/psb.1888Steve Chaplin...
0% (95%CI:-16. 3%~ -9. 8%,P<0. 001);Bempedoic Acid 显著降低了总胆固醇(total cholesterol,TC)水平 (-9. 9% vs. 1. 3%),差异为-11. 2%(95%CI:-13. 6%~ -8. 8%,P<0. 001);Bempedoic Acid 显著降低了载脂蛋白 B 水平(-9. 3% vs. 3. 7%),差异为 -13. 0% (95%CI:-16. ...
2004年3月前,美国Esperion制药公司就致力于调节血脂异常药物的研发工作,研制与开发一种先导候选产品:三磷酸腺苷(ATP)-柠檬酸裂合酶(ATP-citrate lyase,ACL)抑制药——bempedoic acid (贝培多酸),用于降低内源性胆固醇,并通过上调LDL受体降低LDL-C水平升高,减轻肌肉相关副作用。除了作为单一疗法的贝培多酸片剂之外,...
1.6Bempedoic acid Bempedoic acidis an oral lipid-modifying agent that inhibitsadenosine triphosphate citrate lyase, upstream from HMG-CoA reductase, to decrease cholesterol biosynthesis in the liver, upregulate the LDL receptor, and increase clearance of LDL. Although randomized, double-blind, placebo-co...
以口服为给药途径的二羧酸衍生物,其对肝脏三磷酸腺苷–柠檬酸裂解酶(ACL)和腺苷单磷酸–活化蛋白激酶(AMPK) 有双重调节作用,很有潜力成为另一个非他汀类的降脂药.多项临床试验研究表明 bempedoic acid 具有良好的安全性和有效 性.主要从 bempedoic acid 的药物概况,相关背景,合成路线,作用机制和药理作用,临床研究...
Bempedoic acid (ETC-1002), a novel therapeutic approach for low-density lipoprotein cholesterol (LDL-C) lowering, inhibits ATP citrate lyase (ACL), an enzyme involved in fatty acid and cholesterol synthesis. Although rodent studies suggested potential effects of ACL inhibition on both fatty acid an...
研究成果相信,对于他布类药物治果不佳的自愿性冠心病病征,Bempedoic acid治疗可显著降低LDL-C总体。值得注意典故:Anne C. Goldberg et al. Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease The ...
bempedoic acidBempedoic acid (ETC-1002) is a novel drug for the treatment of elevated LDL cholesterol. Bempedoic acid inhibits the enzyme ATP citrate lyase which is upstream of HMG-CoA reductase, the key enzyme of cholesterol biosynthesis and target of statins. Bempedoic acid is administered as ...
Bempedoic acid (ETC-1002) is a new agent that reduces cholesterol synthesis through inhibition of adenosine triphosphate citrate lyase (ACL), an enzyme upstream from 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA). In animal models, bempedoic acid also influences fatty acid synthesis but in humans ...
性。主要从bempedoicacid的药物概况、相关背景、合成路线、作用机制和药理作用、临床研究等方面进行介绍。 关键词:bempedoicacid;三磷酸腺苷–柠檬酸裂解酶;腺苷单磷酸–活化蛋白激酶;降脂药 中图分类号:R972文献标志码:A文章编号:1674-5515(2015)11-1417-05 ...