除了作为单一疗法的贝培多酸片剂之外,还开发与尼曼-匹克C1型类似蛋白的胆固醇吸收抑制药:贝培多酸与依折麦布(ezetimibe)固定剂量组合的复方制剂可抑制小肠中胆固醇的吸收,降低肝脏细胞里胆固醇的含量,促使循环中胆固醇的吸收增加,从而降低血液中胆固醇含量。用于辅助饮食治疗的原发性高脂血症、混合型高脂血症、纯合子...
·世界新药信息·降胆固醇新药———贝培多酸(bempedoicacid)及其与依折麦布(ezetimibe)的复方片剂陈本川(湖北省医药工业研究院有限公司,武汉 430061)摘要2004年 3月前,美国 Esperion制药公司就致力于调节血脂异常药物的研发工作,研制与开发一种先导候选产品:三磷酸腺苷(ATP) 柠檬酸裂合酶(ATPcitratelyase,ACL)抑制...
Bempedoic acid/Ezetimibe(商品名为Nexlizet®)于2020年2月26日获得美国食品药品监督管理局(FDA)批准上市,由Esperion Therapeutics研发与上市。该品种是Esperion最近7天获得FDA批准的第二款新药。第一款是Bempedoic acid。 Nexlizet®是一种由NPC1L1抑制剂(依折麦布)和ATP-柠檬酸合酶抑制剂(Bempedoic Acid)组成的复方...
Bempedoic acid: Inhibits adenosine triphosphate-citrate lyase, which inhibits cholesterol synthesis in the liver and subsequently lowers LDL-C. Ezetimibe: Inhibits absorption of cholesterol in the small intestine. Therapeutic Effect(s): Reduction in LDL-C levels. Reduction in risk of MI or coronar...
Bempedoic acid, an adenosine triphosphate-citrate lyase (ACL) inhibitor, is an antilipemic agent.Uses for Bempedoic AcidDyslipidemiasUsed alone or in combination with ezetimibe as an adjunct to diet and maximally tolerated hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (i.e., statin...
Efficacy and safety of Bempedoic Acid added to ezetimibe in statin-intoler⁃ ant patients with hypercholesterolemia:a randomized,place⁃ bo-controlled study[J]. Atherosclerosis,2018,277:195-203. 收稿日期:2020-06-15 本文编辑:任洁 ·30·
it has been approved for sole use for dyslipidemia treatment for patients who are statin-intolerant or in combination with statin-ezetimibe for those suffering from familial hypercholesterolemia or ASCVD and unable to reach targeted LDL-C values.SummaryBempedoic acid has proven beneficial for further re...
NILEMDO 和 NUSTENDI 在美国以 NEXLETOL 的名义上市(bempedoic acid)片剂和 NEXLIZET (bempedoic acid 和 ezetimibe)片剂。上个月,Esperion向美国食品药品监督管理局(FDA)提交了SNDA,以扩大在美国的适应症,增加使用NEXLETOL和NEXLIZET来降低心血管风险。该公司预计美国食品药品管理局将在2024年上半年批准SNDA。
NEXLIZET tablets, for oral use, contain bempedoic acid, anadenosine triphosphate-citrate lyase (ACL) inhibitor, and ezetimibe, a dietarycholesterolabsorption inhibitor. The chemical name for bempedoic acid is 8-hydroxy-2,2,14,14-tetramethyl-pentadecanedioic acid. The molecular formula is C19H36O5,...
Bempedoic acid(BA)是一款“first-in-class”的ATP柠檬酸裂解酶(ACL)抑制剂,能降低胆固醇的生物合成,从而降低LDL-C水平。而ezetimibe抑制胆固醇运输蛋白NPC1L1的活性,降低胃肠道内胆固醇的吸收和向肝脏的胆固醇运输。与他汀类药物相似,BA也能够降低高敏C反应蛋白(hsCRP)水平,这是一个与心血管疾病相关炎症有关的关键...