Bays, Harold E.Banach, MaciejCatapano, Alberico L.Duell, P. BartonGotto, Antonio M., Jr.Laufs, UlrichLeiter, Lawrence A.Mancini, G. B. JohnRay, Kausik K.Bloedon, LeAnne T.Sasiela, William J.Ye, ZhanBallantyne, Christie M.Louisville Metab &Journal of clinical lipidology...
Bempedoic Acid (BA) is a novel Lipid-Lowering Therapy (LLT). We performed a systematic review and meta-analysis to assess the efficacy and safety of BA in patients with hypercholesterolemia. Methods PubMed, Scopus, and Cochrane library databases were searched for randomised controlled trials evaluat...
Recent studies from Australia and Europe suggest bempedoic acid may be more cost effective compared to statins [54,55]. Considering the above-mentioned benefits, bempedoic acid should be explored as an additional therapy to achieve required LDL-C levels in statin-intolerant patients [54,55]. Chall...
The objective of CLEAR Tranquility (NCT03001076) was to evaluate the efficacy and safety of bempedoic acid when added to background lipid-modifying therapy in patients with a history of statin intolerance who require additional LDL-C lowering. Methods: This phase 3, multicenter, randomized, double...
Bempedoic acid (Nexletol; Esperion) and bempedoic acid and ezetimibe (Nexlizet; Esperion) are the only LDL-C lowering non-statin drugs indicated for primary prevention patients.
This prespecified analysis of the Cholesterol Lowering via Bempedoic Acid, an ATP Citrate Lyase (ACL)–Inhibiting Regimen (CLEAR) Outcomes trial
The safety profile was consistent across subgroups. Conclusions Bempedoic acid is generally safe and well tolerated among patients with hypercholesterolemia who require additional LLT.doi:10.1016/j.jacl.2020.08.009Harold E BaysMaciej BanachAlberico L Catapano...
Bempedoic acid (BA) is a first-in-class ATP citrate lyase inhibitor that lowers LDL-C levels. There is limited data on the use of BA and BA + ezetimibe (EZE) fixed-dose combination (FDC) in clinical practice. PURPOSE. The purpose of this snapshot of 1-year follow-up data from the ...
Thus, we aim to evaluate the benefit and safety of bempedoic acid use for the prevention of cardiovascular events and diabetes.We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials with no language restriction from inception until March 3, 2020. Pairs of reviewers ...
META-ANALYSIS OF SAFETY AND EFFICACY OF BEMPEDOIC ACIDdoi:10.1016/S0735-1097(20)32620-6Muhammad U KhanMuhammad KhanShahul ValavoorAhmad Naeem LoneWest VirginiaJournal of the American College of Cardiology