However, the amount of brown adipose tissue decreases over a person’s lifetime; adults have very little of it. Then, finally, the beige fat cells. These can also produce heat, albeit somewhat less well than brown fat cells. Beige fat cells occur in adults as well: scattered through...
The hope of the discovery of beige fat is that it may lead to new treatments for obesity and diabetes. One proposed solution may be a drug that would stimulate the production or brown or beige fat over white fat to increase weight loss. But as Neporent reported, Dr. David Katz...
Brown adipocytes are located in dedicated depots and express constitutively high levels of thermogenic genes, whereas inducible 'brown-like' adipocytes, also known as beige cells, develop in white fat in response to various activators. The activities of brown and beige fat cells reduce metabolic ...
Sci. USA http://dx.doi.org/10.1073/ pnas.1519132113 (2016) METABOLISM Beige fat boosts metabolism Human 'beige' fat cells implanted in mice can improve the animals' glucose metabolism and liver-fat profiles. The presence of beige fat — brown fat cells within white fat-storing tissue — is...
Sci. USA http://dx.doi.org/10.1073/ pnas.1519132113 (2016) METABOLISM Beige fat boosts metabolism Human 'beige' fat cells implanted in mice can improve the animals' glucose metabolism and liver-fat profiles. The presence of beige fat — brown fat cells within white fat-storing tissue — is...
The activities of brown and beige fat cells reduce metabolic disease, including obesity, in mice and correlate with leanness in humans. Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic...
To test if CD81 marks beige fat progenitors, we isolated CD81+ and CD81− cells from the SVF of mouse Ing WAT by FACS (Figure 2A). After reaching confluency in culture, the sorted cells were differentiated under adipogenic conditions (Figure S2A). Oil-Red-O staining showed that CD81+...
beige fat in mice. They traced the signaling chain further, showing that IL-25 exerted its effects through two other cytokines, which in turn regulated immune cells called macrophages. Those cells acted on neurons that terminate in the beige fat tissue, promoting an increase in production...
Sci. USA http://dx.doi.org/10.1073/ pnas.1519132113 (2016) METABOLISM Beige fat boosts metabolism Human 'beige' fat cells implanted in mice can improve the animals' glucose metabolism and liver-fat profiles. The presence of beige fat — brown fat cells within white fat-storing tissue — is...
Sci. USA http://dx.doi.org/10.1073/ pnas.1519132113 (2016) METABOLISM Beige fat boosts metabolism Human 'beige' fat cells implanted in mice can improve the animals' glucose metabolism and liver-fat profiles. The presence of beige fat — brown fat cells within white fat-storing tissue — is...