Ovariectomy decreases the preference in a cocaine-induced CPP test, and decreases the amount of dopamine and serotonin present in the ventral tegmental area (Russo et al., 2003), two neurochemicals that are central to the motivation and reward signaling pathway. Show abstract Serotonin neurons in...
This chapter describes some of the general aspects of behavioral pharmacology, summarizes earlier results in the field concerning the role of serotonin and dopamine, and discusses some recent results, which may hopefully serve as a trigger for future lines of research. An increase in dopaminergic act...
Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference. The interaction of dopamine and glutamate in limbic brain regions mediates behaviors associated with psychostimulants, which act in part to increase dopami... Heusn...
Depression and anxiety are more common among females than males and represent a leading cause of disease-related disability in women. Since the dopamine D1-D2 heteromer is involved in depression- and anxiety-like behavior, the possibility that the receptor complex may have a role in mediating ...
Symptoms like not getting out of bed, bathing/grooming, or refusing to participate in calls/texting may signal a drop in dopamine, a neurotransmitter responsible for rewards, consequences, and motivation. If others make your life happen more than you care to, this warrants treatment. Passive-Aggr...
However, it is possible that this finding is impacted by relatively low sample size. To explore this possibility, increase the robustness of the statistical analysis, and explore the generalizability of these findings across all three experiments, we combined the results from experiment 1–3 within ...
Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor binding. Epidemiological evidence indicates that prenatal nutritional deprivation may increase the risk of schizophrenia. The goal of these studies was to use an an... AA Palmer,AS Brown,D Keegan,....
These results suggest that acupuncture reduces extracellular DA release and metabolic neuronal activity in the NAc through activation of mGluR2/3 and suppresses METH-induced affective states and locomotor behavior. 展开 关键词: acupuncture brain temperature dopamine locomotor activity mGluR2/3 ultrasonic ...
We found that long-term and repeated, but not single, NAc-DBS induced robust antidepressant responses in CUMS mice. Moreover, even a single trial NAc-DBS led to the elevation of the γ-aminobutyric acid (GABA) neurotransmitter, accompanied by the increase in dopamine (DA) neuron activity in...
(1) cocaine has been shown to increase the phosphorylation of DARPP-32 at threonine 34 (T34) selectively in striatonigral neurons (Bateup et al, 2008) and Role of GRK2 in the brain dopamine system TL Daigle et al 2455 Figure 3 Cocaine-induced DARPP-32 phosphorylation is enhanced in the...