Differences in thyroid function were produced in mice by genetic selection based on the criterion of I 131 release from the thyroid gland. Two experiments examined open-field behavior, water-maze learning, seizure susceptibility, and various endocrine and organ measures in the incipient strains at ...
Methods Mouse surgery and treatment. All experiments were performed in accordance with the National Institutes of Health guidelines and regulations. The animal protocol was approved by the Massachusetts General Hospital (Boston, Massachusetts) Standing Committee on the Use of Animals in Research and ...
Behavioral Experiments. All behavioral experiments were conducted using young adults over 8 weeks of age. Mice were handled for one week prior to behavioral testing. Mice were transferred to the experimental room 30 mins prior to the start of testing. All apparatus was cleaned with 70% ...
In the present review we describe such basic considerations in planning experiments, selecting strains of mice, and propose groups of behavioral tasks suitable for a reliable detection of differences in specific behavioral domains in mice. Screening of general health and neurophysiologic functions (...
Studying animals in behavioral experiments has been a cornerstone of psychological research, but whether the observations are relevant for human behavior has been unclear. Weill Cornell Medical College researchers have identified an alteration to the DNA of a gene that imparts similar anxiety-related be...
Electrophysiological experiments finally demonstrated that the E/I balance in these mice is altered by modification of both inhibitory and excitatory synaptic transmission. On the basis of the reported changes in PV expression patterns in several, mostly genetic rodent models of ASD, we propose that ...
as detailed in the following sections, and all mice were euthanized 4 days after the behavioral experiment. Brain tissues of the sacrificed mice were dissected and frozen at − 80 °C until further analyses. All experiments were performed according to methods approved by the ethics committee of...
Data presented is the aggregate of all experiments. (F–H) Behavioral outcomes in offspring of colonized mice from selected eight donors stratified by mouse sex: (F) Repetitive behavior by marble burying test, (G) time socializing in direct social interaction, and (H) distance traveled in open...
Two separate experiments were designed to assess the effects of ozone exposure on outbred CD-1 mice. In the first experiment, adult males were exposed continuously to O 3 at 0, 0.3, or 0.6 ppm for 30 days and their behavior was assessed in a 5-min open-field test on exposure days 4 ...
(b) Two immobile mice with different angles (α) in water. White lines indicate how the angles were measured. Pictures of mice were taken in experiments shown in e and f. (c) Significant difference in α of WT and Gabra5+/ − mice. (d) Fim plotted as a function of α shows a ...