Macs2 bdgdiff的原理是基于两个重要的统计模型:基因组均一性模型和差异性模型。基因组均一性模型假设两个实验之间的测序深度分布是相同的,差异性模型则假设两个实验之间的测序深度分布存在差异。Macs2 bdgdiff通过比较这两个模型的拟合度来确定差异。 具体来说,Macs2 bdgdiff首先会对两个实验的测序深度数据进行平滑处...
I had one treated sample and one non-treated sample, but without Chip-Seq mock (or background control). But I want to identify regions that are differentially histone modification between control and treated. MACS2 bdgdiff is a prefect t...