Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteinsSome proteins require completion of folding before translocation across a membrane into another cellular compartment. Yet the permeability barrier of the membrane should not be compromised and mechanisms ...
Bcs1, a homo-heptameric transmembrane AAA-ATPase, facilitates folded Rieske iron-sulfur protein translocation across the inner mitochondrial membrane. Structures in different nucleotide states (ATP纬S, ADP, apo) provided conformational snapshots, but the kinetics and structural transitions of the ATPase ...