[1] Faderl S, Kantarjian H, Talpaz M, Estrov Z. Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia. J Am Soc Hematol. 1999;94(5):1495–503.[2] Mertens, Fredrik , et al. The emerging complexity of gene fusions in cancer. Nature Reviews Cancer 15.6...
[2] Jinawath N,Norris-Kirby A,Smith BD,et al. A rare e14a3 ( b3a3) BCR-ABL fusion transcript in chronic myeloid leukemia. J Mol Diagn,2009; 11( 4) : 359 - 363. [3] Hochhaus A,Reiter A,Skladny H,et al. Novel BCR-ABL fusio...
[1]Faderl S, Kantarjian H, Talpaz M, Estrov Z. Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia. J Am Soc Hematol. 1999;94(5):1495–503. [2]Mertens, Fredrik , et al.The emerging complexity of gene fusions in cancer. Nature Reviews Cancer 15.6(2015...
The emerging complexity of gene fusions in cancer. Nature Reviews Cancer 15.6(2015):371-381. [3] Mughal TI, Radich JP, Deininger MW, Apperley JF, et al. Chronic myeloid leukemia: reminiscences and dreams. Haematologica. 2016 May;101(5):541-58. [4] Gao, Q. , et al. Driver Fusions...
ABL1属于小细胞质酪氨酸激酶家族,仅由两个成员组成:由ABL1基因编码的ABL1和由ABL2基因编码的ARG(ABL-related gene , ABL相关基因)。超过90%的ABL2结构域结构与ABL1相同,ABL1或ABL2与Ets变体基因6(Ets variant gene 6, ETV6)的融合与淋巴细胞白血病或髓性...
Definition BCR-ABL1is a hybrid (fusion or chimaeric) gene that arises when genomicDNAof theBCRgene on chromosome 22 and of theABL1gene on chromosome 9 breaks and recombines. TheBCR-ABL1hybrid gene is transcribed to produce a hybrid mRNA that is subsequently translated into a functional BCR-...
来源: https://www.labmedica.com/molecular-diagnostics/articles/294801066/first-of-its-kind-ngs-assay-for-precise-detection-of-bcrabl1-fusion-gene-to-enable-personalized-leukemia-treatment.html
Mycoplasma Status: Negative II. Background Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia...
A 68-Year-Old Man with a Cytogenetic Diagnosis of Chronic Myeloid Leukemia and Bone Marrow Findings of Philadelphia Chromosome Translocation Between the Long Arm of Chromosomes 9 and 22, Leading to the BCR-ABL1 Fusion Gene and V617F Mutation in the JAK2 Gene. Am J Case Rep. 2023 Mar 3;...
Mycoplasma Status: Negative II. Background Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia...