Many international efforts have been done to standardize PCR assays, an international conversion factor has been introduced which allows comparison of results between laboratories, and response criteria have been defined based on % BCR-ABL1/ABL1 values. A drawback of the current state is that ...
Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion gene. Both the presence and the levels of BCR/ABL1 expression seem to be critical for CML progression from chronic phase (CP) to blast crisis (BC). After the oncogenic translocation, the BC
In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors (TKIs), especially in the absence of kinase domain mutations in BCR-ABL1, is poorly understood. Through deep molecular profiling, we uncovered three transcriptomic
Treatment of cells transformed by BCR-ABL1 resulted in a dose-dependent inhibition of proliferation and induction of apoptosis. These results were confirmed in primary CML and Ph+ ALL cells as well as in committed progenitors from patients with CML. Importantly, imatinib exhibited little impact on...
Most importantly, downregulation of WASP contributes to the resistance to apoptosis and to BCR–ABL1-induced tumor- igenesis. Therefore, WASP may serve as a molecular marker of prognosis, as well as a potential target for combined antitumor therapies for CML. Results WASP is downregulated in BCR...
目的探讨BCR-ABL阴性骨髓增殖性肿瘤(MPN)患者右心功能损伤评估指标的临床意义。 方法回顾性分析2015年1月至2021年8月连云港市第二人民医院及江苏省人民医院诊断的208例BCR-ABL阴性MPN患者的临床资料,其中原发性骨髓纤维化(PMF)63例、真性红细胞增多症(PV)39例、原发性血小板增多症(ET)106例,比较3组患者临床特征...
Chronic myeloid leukemia is associated with a more favorable prognosis following treatment with BCR::ABL1 tyrosine kinase inhibitors (TKIs). Nonetheless, about 40% of affected individuals with CML display resistance or intolerance towards BCR::ABL1 TKIs.
Bcr-Abl most patients with chronic myelogenous leukemia (CML). More than 90% of CML cases are caused by a chromosomal abnormality that results in the formation of a so-called Philadelphia chromosome. This abnormality is a consequence of fusion between the Abelson (Abl)tyrosine kinase gene at ...
the inheritance is compatible with an autosomal dominant trait with disease that results from retroviral infection is polyclonal, low penetrance, in which only the predisposition to acquiring suggesting that the expression of BCR-ABL1 alone is sufficient to induce the disorder in mice.11 Furthermore,...
BCR/ABL1 causes dysregulated cell proliferation and is responsible for chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1-ALL). In addition to the deregulatory effects of its kinase activity on cell