The Bcr-Abl gene mutation detection liquid-phase chip has extreme good signal-noise ratio, and cross reaction is basically unavailable between a designed probe and the anti-tag sequence. The designed ASPE primer has extreme good specificity and can exactly distinguish the each type of mutational ...
BCR-ABL is a mutation, also known as the Philadelphia (Ph) chromosome, which is formed by a reciprocal chromosomal translocation of the BCR gene on chromosome 22 with the ABL1 gene on chromosome 9. Each of the covered 39 countries color-coded and fully-sourced market models are equipped ...
ABL gene 位于chromosome 9，其功能为非受体型酪氨酸激酶。由于philadelphia chromosome translocation 而形成的BCR-ABL表达产物具有高度的酪氨酸激酶活性,即t（9;22）异常引导了chromosome 9和22之间的DNA交换，ABL的3’端从chromosome 9转移到chromosome 22上，并且将原本在chromosome 22上的BCR gene 切断，重新加入组合...
在TKI治疗过程中,CALR突变和BCR-ABL1双阳性克隆对TKI药物敏感,而CALR阳性BCR-ABL1阴性克隆对TKI药物不敏感,且对CALR突变的动态检测结果发现,CALR的突变负荷呈现一个逐步缓慢升高的趋势,这也就能解释患者BCR-ABL1水平即使达到分子学水平的缓解,但是...
gene that arises when genomicDNAof theBCRgene on chromosome 22 and of theABL1gene on chromosome 9 breaks and recombines. TheBCR-ABL1hybrid gene is transcribed to produce a hybrid mRNA that is subsequently translated into a functional BCR-ABL1 protein. TheBCR-ABL1mutation causes and is diagno...
Clinical resistance to STI⁃ 571 cancer therapy caused by BCR⁃ABL gene mutation or amplification [ J] . Science,2001,293(5531) :876⁃880. [5] Soverini S, Hochhaus A, Nicolini FE, et al. BCR⁃ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with ...
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification Science, 293 (2001), pp. 876-880 View in ScopusGoogle Scholar Goss et al., 2006 V.L. Goss, K.A. Lee, A. Moritz, J. Nardone, E.J. Spek, J. MacNeill, J. Rush, M.J. Comb, R.D....
位, 而BCR-ABL1 为为是为 性。 Ø 为NGS WGS 为为,为为一个 新的BCR-ABL1 融合基因 (e14a3). 全基因为为序为为新的融合方式:e14a3 Lyu et al. Molecular Cytogenetics (2016) 9:47 DOI 10.1186/s1303901602575 A novel BCRABL1 fusion gene and its transcript in a CML ...
BCR-ABL1 检测是 阴性。 ? 经 NGS WGS 检测,发现 一个新的 BCR-ABL1 融合 基因 (e14a3). 全基因组测序发现新的融合方式: e14a3 Lyu et al. Molecular Cytogenetics (2016) 9:47 DOI 10.1186/s13039-016-0257-5 A novel BCR-ABL1 fusion gene and its transcript in a CML case. ABL 激酶...
0, NO. 0, 1–7/10.10802016.1219821全基因组测序发现新的融合方式:e14a3A novel BCR-ABL1 fusion gene and its transcript in a CML case.CML案例, 细胞遗传学分析和FISH检测结果费城易位, 而BCR-ABL1检测是阴性。经NGS WGS检测,发现一个新的BCR-ABL1融合基因(e14a3).Lyu et al. Molecular Cytogenetics...