Leukemia BCR-ABL Fusion Gene Real Time RT-PCR KitCat. No.: TR
McWhirter JR, Wang JY, Effect of Bcr sequences on the cellular function of the Bcr-Abl oncopro- tein. Oncogene 1997; 15: 1625-34.McWhirter JR,Wang JYJ.Effect of BCR sequences on the cellular function of the BCR-ABL oncoprotein. Oncegene . 1997...
1.Bcr-Abl （1）关于Bcr-Abl的介绍及TKI BCR gene位于chromosome 22 的长臂上（22q11），是种十分复杂的分子，其表达产物具有许多功能的结构域，主要作用于2种信号通路，即磷酸化和GTP binding。ABL gene 位于chromosome 9，其功能为非受体型酪氨酸激酶。由于philadelphia chromosome translocation 而形成的BCR-ABL...
英文翻译Bcr/Abl fusion gene 名词定义人体细胞第9号染色体上的Abl原癌基因与第22号染色体上的Bcr基因相互易位形成的融合基因。可引起蛋白激酶持续性激活,使白细胞过分增殖而出现慢性粒细胞白血病。 所属学科免疫学>免疫病理、临床免疫>肿瘤免疫 名词审定免疫学名词审定委员会 ...
BCR/ABLPOSALL, the break within the BCR gene occurs in the major breakpoint cluster region (M-bcr), resulting, when joined with a portion of c-ABL fromchromosome 9, in a b2a2 or b3a2 fusion transcript encoding a protein of 210,000 dalton molecular weight (p210BCR-ABL). In the ...
BCR/ABL gene (jēn) A fusion gene produced when a segment of the Abelson protooncogene, ABL, from chromosome 9, translocates to the major breakpoint cluster region (M-BCR) on chromosome 22. The fusion gene produces a specific protein, P210. This fusion gene is found in chronic myelocytic...
1.Bcr-Abl (1)关于Bcr-Abl的介绍及TKI BCRgene位于chromosome22的长臂上(22q11),是种十分复杂的分子,其表达产物具 有许多功能的结构域,主要作用于2种信号通路,即磷酸化和GTPbinding。ABLgene位于 chromosome9,其功能为非受体型酪氨酸激酶。由于philadelphiachromosometranslocation ...
关键词: 骨髓增殖性疾病;融合蛋白质类,bcr-abl;心室功能,右;诊断 ABSTRACT ObjectiveTo investigate the factors influencing the right heart dysfunction in myloproliferative neoplasm (MPN) patients with BCR::ABL fusion gene-negative. MethodsA retrospective case-control study was conducted. A total of 130...
The BCR-ABL1 fusion gene creates a constitutively active tyrosine kinase, which leads to uncontrolled proliferation. ABL1 T315I is a gatekeeper mutation that lies within the hinge region of the protein kinase domain of the Abl1 protein (PMID: 18794843). T315I has been demonstrated to occur as...
ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants ...