BCLAF1 (BCL2-associated transcription factor 1)doi:10.4267/2042/46079JP McPhersonJean-Loup Huret (Editor-in-Chief) ; INIST-CNRS (Publisher)
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we have characterized Bcl-2-associated transcription factor (Bclaf1) during rodent retinogenesis. Bclaf1 expression is restricted to early-born cell types, such as ganglion,
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Nrf2 is a transcription factor which upregulates antioxidant genes, producing enzymes to reduce ROS into metabolizable products, such as H2O2. Nrf2 is kept inactive in the cytosol by a Keap1–Nrf2 complex. Elevated ROS levels break up this complex, allowing Nrf2 to enter the nucleus and ...
AID mRNA was assessed by semi-quantitative reverse transcription PCR (RT-PCR) using primers (5′-AGGCAAGAAG-ACACTCTGGACACC-3′ and 5′-TCAAAGTCCCAAAGTACGAAATGC-3′) with β-actin as a positive control. Statistical analysis Risk of transformation over time and time to transformation (TTT)...
The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor pathway has been one of the key pathways studied, but has been characterized as a “double-edged sword” due to its pivotal role in the promotion of inflammation and tumor development, as well ...
Similarly Mcl-1 expression increased with increasing tumor thickness (P<0.09) and dermal tumor mitotic rate (P<0.17). Bcl-2 expression was positively correlated with expression of the transcription factors microphthalmia transcription factor (MITF) and nuclear AP-2 whereas Bcl-XL (and Mcl-1) ...
Reporter assays and electrophoretic mobility shift assays reveled that the −938C>A BCL2 promoter polymorphism significantly affects promoter activity and transcription factor binding in prostate cancer cells. Significantly higher BCL2 mRNA expression was observed in primary prostate carcinomas derived from...
The apparent downregulation of BAX is probably attributed to the EBV latent membrane protein 1 (LMP1). This antiapoptotic protein was shown to protect B-cells from apoptosis by inhibition of BAX transcription through activation of the NFKB (P50/P65 heterodimer), which reduces BAX promoter activity...