28. Li S, Weiss VL, Wang XJ, Desai PA, Hu S, Yin CC, Tang G, Reddy NM, Medeiros LJ, Lin P. High-grade B-cell lymphoma with MYC rearrangement and without BCL2 and BCL6 rearrangements is associated with...
This letter published in the Blood Cancer Journal discusses limited stage high-grade B-cell lymphoma with MYC, BCL2, and/or BCL6 rearrangements. The authors conducted a retrospective analysis of patients with this lymphoma and found that intensive chemotherapy and R-CHOP had similar survival rates...
×200); C-E: The tumor cells were positive for CD10 and BCL6 and negative for MUM1 (EnVision stain, ×200), indicating a GCB type; F-G: Both MYC and BCL2 were positive, indicating its double expression st...
内容提示: CMYC 、 BCL 2 、 BCL 6蛋白表达与弥漫性大 B 细胞淋巴瘤预后关系的研究王辉 邓旭 谢军 赵伟 李青 △(常州市第一人民医院病理科,江苏 常州 213000 ) 摘 要 目的 探讨 CMYC 、 BCL 2 与 BCL 6 蛋白表达与弥漫性大 B 细胞淋巴瘤( diffuse large B cell lymphoma ,DLBCL )患者临床特征及...
NalanAkyurek, AysegulUner, MustafaBenekli, IbrahimBarista. (2012) Prognostic significance of MYC, BCL2, and BCL6 rearrangements in patients with diffuse large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab. Cancer 118 , 4173-4183 /...
BackgroundHigh-grade B-cell lymphomas (HGBLs), with c-Myc,Bcl2, and/or Bcl6 rearrangement, are aggressive neoplasms with poor clinical outcomes. Cyclin D1 is a proto-oncogene that is generally expressed by mantle cell lymphoma, its variants, and many other neoplasms.AimThe aim ...
结论淋巴母细胞淋巴瘤组织中可以检测到Bcl.2、Bcl.6和c.Mye蛋白的阳性表达以及相应染色体异常,但是蛋白表达与基因异常间无统计学相关性,提示了bcl.2、bcl.6和c.myc基因异 天津医科大学博士学位论文AbstractObjectiveLymphoblasticlymphoma(LBL)isaneoplasmofimmatureorprecursorlymphoidcells.Itbelongstoararehi曲-grade...
High-grade B-cell lymphomas with MYC, BCL2, and BCL6 rearrangements (triple hit lymphoma) are uncommon. We studied the clinicopathologic features of 40 patients with triple hit lymphoma and compared them to 157 patients with MYC/BCL2 double hit lymphoma
Bcl-6 and BCL-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: correlation with 3q27 and 18q21 chromosomal abnormalities. Hum Pathol. 1999;30:803–8. Article CAS PubMed Google Scholar Iqbal J, Neppalli VT, Wright G, Dave BJ, Horsman DE, Rosenwald A, et ...
Amplification of the BCL2/JH translocation at the major breakpoint region (mbr) and minor cluster region (mcr) was performed as described previously.11 Positive controls consisted of DNA extracted from the human B-cell lymphoma cell lines RL-7 for the mbr and DHL-16 for the mcr. Negative ...