30 M Certo, G Moore Vdel, M Nishino, et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members Cancer Cell, 9 (5) (2006), pp. 351-365 View in ScopusGoogle Scholar 31 S Al-Harbi, BT Hill, S Mazumder, et al. An antiapoptotic BCL...
W Huang da, BT Sherman, RA Lempicki Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat Protoc, 4 (1) (2009), pp. 44-57 Google Scholar [58] AL Jackson, PS. Linsley Recognizing and avoiding siRNA off-target effects for target identification and th...
Single-cell transcriptional profiling of CD8+T cells and cDC1 in tumors and TdLNs from B16-OVA tumor-bearingBcl9/Bcl9ldeficiency mice.aIllustration of experiment and analysis process of single-cell transcriptional analysis.bTSNE plots of clustering process and marker genes (Zbtb46for DCs,Cd68for ...
Mitochondrial membrane potential (MMP) assays Cells were seeded into a 96-well plate (Corning) and treated with vMO for 48 h. Next, cells were stained with JC-10 solution for 30 min and photographed using the high content analysis system (PerkinElmer, MA, USA). Flow cytometry analysis ...
A representatloivadeinogfc2onbtriooll.oAgriecparlesreenptalitcivaeteofs2ibsioslhogoiwcanl r;e(pcli)caItmesmisushnoowcny;t(oc)cIhmemmuincoaclyatoncahleymsiicsaloafnalysis FFPE basal A, MDA-Mof BFF-4P6E8bacsealllsA,aMndDAb-aMsBa-l4B68, cCelAlsLa-n1d2b0asaanl dB, MCADLA-1-2M0 aBn-d...
E2663BT2BT2 is a novelbranched-chain α-ketoacid dehydrogenase complex kinase (BDK)inhibitor wieh an IC50 of 3.19 μM. E3020Hedyotic Diffusa ExtractHedyotic Diffusa Extract is extracted fromHedyotic diffusa, of which polysaccharides inhibit the growth of CNE2 cells in a dose-and-time-dependen...
塞利尼索作为全球首个口服选择性XPO1抑制剂,通过抑制XPO1,发挥强大的抗肿瘤作用,可协同其他药物(化疗、BTKi、BCL-2i、PD-1i/PD-L1i)增强抗肿瘤活性、克服耐药,是目前唯一获得FDA批准用于治疗R/R DLBCL的口服靶向药物(包括FL转化...
J Clin Oncol 2012; 30: 3452–3459. Google Scholar, Crossref, Medline, ISI4. Horn, H, Ziepert, M, Becher, C. MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood 2013; 121: 2253–2263. Google Scholar, Crossref, Medline, ISI5...
npb(5μm)在mcf7、bt474、caov-3、ishikawa、aspc-1和dld-1细胞中的作用。使用apotox-glotm三重分析试剂盒评估(b)细胞生存力和(c)胱天蛋白酶3/7活性。所有测定如研究方法中所述进行。使用graphpadprism5通过非配对双尾t检验评估统计学显著性(p<0.05被认为是显著的)。柱代表一式三份测定的平均值;条,±...
在免疫抑制途径中发现的非限制性免疫抑制检查点分子可以包括lag3(cd223)、a2ar、b7-h3(cd276)、b7-h4(vtcn1)、btla(cd272)、btla、cd160、ctla-4(cd152)、ido1、ido2、tdo、kir、lair-1、nox2、pd-1、pd-l1、pd-l2、tim-3、vista、siglec-7(cd328)、tigit、pvr(cd155)、tgfβ或siglec9(cd329)...