Interestingly, SP600125, a JNK inhibitor, was potent in cell growth inhibition and apoptosis induction of both parental and IMT-resistant NphA2 and MR87 cells. Moreover, NphA2 and MR87 and their IMT-resistant sublines were sensitive to ABT-199, a specific BCL2 inhibitor. The combination of...
Here, we report on a screen conducted on 19 DLBCL and other lymphoma cell lines, of drug susceptibility to a selection of 126 compounds that are approved for clinical use. Our results K. Bertram et al. 1037 suggest that the Bcl-2 inhibitor venetoclax, in combination with the BTK inhibitor...
500 µL 有货 查看价格 批量或定制请求 产品信息 应用 建议稀释比 已发表文章 流式细胞分析 (Flow) Assay-Dependent - 产品规格 种属反应 Human 宿主/亚型 Mouse / IgG1 分类 Monoclonal 类型 Antibody 克隆号 100 抗原 Human B cell leukemia/lymphoma 2 (Bcl-2) antigen ...
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the...
Novel isoindoline or isoquinoline derivatives of formula (I) useful as Bcl-2 anti-apoptotic inhibitors SPACE FOR FORMULA in which Het, R3, R4, R5, R7, R8, R9, T, p, p ', q, and q' they are as defined in the description and pharmaceutical compositions containing them. The compounds ...
to 9.7 months. In terms of safety, lisaftoclax, at doses ranged from 800-1200 mg, in combination with other therapeutic agents showed favorable tolerability and no drug-drug interactions (DDIs). This is the first ever report on the long-term treatment with a Bcl-2 inhibitor at high dos...
Despite the initial success at prolonging survival rates compared to prior standards therapies, available follow-up data with FLT3 inhibitor therapies show that this class of drug is plagued by short duration of response and nearly inevita- ble relapse when given combined with other AML thera- ...
(Figs.7and8). These results open the way to the design of new antivirals that could interfere with these hosts–viral TMD–TMD interactions. Of interest, MyxV-FL behaved as a strong apoptosis inhibitor regardless of the stimuli. In contrast, HHV8-FL worked better as an apoptosis inhibitor ...
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of...
We also revealed reduced activity of MCL-1 inhibitors in the presence of stromal support as a drug-class effect that was overcome by concurrent Bcl-xL or Bcl-2 inhibition. Finally, we demonstrated heterogeneous Bcl-2 family deregulation and MCL-1 inhibitor cross-resistance in carfilzomib-resistant...