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Present address: Samuel Lunenfeld Research Institute, Toronto, Canada Authors and Affiliations Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Public Health, Baltimore, 21205, Maryland, USA J M Hardwick Department of Pharmacology and Molecular Sciences, Johns Hopkins...
This work was supported by grants from the Canadian Institutes of Health Research (CIHR) (RGK and PL) and from the National Cancer Institute of Canada (RGK). RGK is a Howard Hughes Medical Institute International Research Scholar and CIHR Senior Scientist. PL is a CIHR New Investigator. We ...
Sunnybrook Research Institute and Departments of Biochemistry and Medical Biophysics, University of Toronto, Toronto, ON, Canada David W. Andrews Contributions G.B. and D.G.E. conceived, designed, and coordinated the study with further inputs from D.W.A. T.V., B.K.S., E.X., S.K.,...
potential for strong signaling to mitochondria and thereby inhibiting apoptosis.101BAX/BAK and BH3-only proteins may oppose calcium leakage by binding BCL-2/BCL-XLor IP3R, increasing calcium stores and promoting apoptosis.102,103However, there are many areas of controversy and additional models ...
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Seymour, National Cancer Institute of Canada Clinical Trials, G Erlotinib in previously treated non-small-cell lung cancer N. Engl. J. Med, 353 (2005), pp. 123-132 View in ScopusGoogle Scholar 10 R. Rosell, T. Moran, C. Queralt, R. Porta, F. Cardenal, C. Camps, M. Majem, G....
Enriched AML cells were thawed, counted, pelleted, and resuspended at 2 × 106 cells/mL in StemSpan H3000 defined, serum free-medium (StemCell Technologies, Vancouver, BC, Canada). Leukemia samples were transferred to individual wells or cytometry tubes (Falcon 2052, BD Biosciences, San Jose,...
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streptomycin (Gibco, USA) and 4 mM L-Glutamine (Gibco, USA). Primary patient-derived AML cells were isolated using Ficoll gradients and were cultured in IMDM (Thermo Fisher Scientific, USA) supplemented with 15% BIT 9500 Serum Substitute (STEMCELL Technologies, Canada), 100 ng/ml stem cell...