Researchers in four countries will soon start a clinical trial of an unorthodox approach to the new coronavirus. They will test whether a century-old vaccine against tuberculosis (TB), a bacterial disease, can rev up the human immune system in a broad way, allowing it to better fight the vi...
The tuberculosis (TB) vaccine Bacillus Calmette〨uérin (BCG) was introduced 100 years ago, but as it provides insufficient protection against TB disease, especially in adults, new vaccines are being developed and evaluated. The discovery that BCG protects humans from becoming infected with ...
Vaccination of cattle prevents the spread of the disease in populations by reducing the number and size of the lesions, and the load of bacteria (rather than by preventing infection; very similar to what happens in humans, vaccine does not prevent infection but can reduce severe extrapulmonary ...
Bacillus Calmette–Guérin (BCG) vaccine has been shown to be efficacious in protecting against Mtb in early childhood and, more interestingly, at decreasing overall morbidity and mortality to other infectious diseases, suggesting that the protective mechanism of BCG is not limited to only tuberculosis...
analysis of COVID-19 data from countries with universal BCG vaccination, discontinued vaccination, and countries that never adopted BCG vaccination suggests that disease incidence and morbidity are reduced in countries with universal BCG immunization compared with those that have not adopted the vaccine....
(BCG) vaccine, which has been suggested to play a role on the SARS-CoV-2 infection [15]. This is the only approved anti-tuberculosis vaccine which was originally developed to combat tuberculosis in the twentieth century and has been already administered worldwide in more than 4 billion doses...
to a controlled trial of BCG vaccine conducted in 1968 in southern India in which vaccination was found to produce no protective effect against tuberculosis... WH Organization - 《World Health Organization Technical Report》 被引量: 38发表: 1969年 Protective effect of BCG among children vaccinated...
This cohort study evaluates the use of BCG vaccine in patients with non–muscle-invasive bladder cancer who were at risk for Alzheimer disease and related
1.1.1Protective efficacy of BCG vaccine Several studies have been carried out to access protective efficacy ofBCG vaccine. These studies have shown large discrepancies in efficacy of BCG depending on the study design or in the geographic areas in which they were performed (Figure 2). Various repo...
Fig. 3. Antiviral immunity provided by BCG vaccine through trained immunity involves the discharge of IL-1β, TNF-α and IL-6 from epigenetically modified monocytes which confer early protection against SARS-Cov2. Moreover, BCG vaccination protocols and bacteria strains used are different among BCG...