Despite the questionsabout its efficacy,only a few countries donot use BCG for routinevaccination. This situationmay change in thefuture, however, withrecent evidence thatolder versions of thevaccine may be moreeffective than some ofthe more recentstrains.6In the UnitedStates, BCG generally isnot ...
Intravesical bacillus Calmette-Guérin is the current first-line treatment for high-grade nonmuscle-invasive bladder cancer; however, a substantial proportion of patients are unresponsive to bacillus Calmette-Guérin treatment. While cystectomy...
These advances are guiding the identification of biomarkers for reactogenicity and efficacy, and the rational design of immunotherapeutic strategies to eliminate the use of live bacilli for bladder cancer therapy.doi:10.1038/nrurol.2013.194Christine Gan...
therapies andvisceral metastases.70Although there are many new treatments taking advantage of known molecular mutations and mechanisms associated with advancedurothelial cancer, there is no established link at this time regarding the impact of theurinarymicrobiome on the efficacy of thesesystemic treatments...
Meaning The findings of this study suggest that bladder cancer treatment with BCG vaccine was associated with decreased mortality, and decreased ADRD, independently; clinical trials are required to study its efficacy beyond treatment in patients with bladder cancer. Abstract Importance The BCG vaccine—...
New TB vaccines have been in development for over 30 years and now show progress, particularly in the prevention of progression from TB infection to disease in young adults. The role of BCG in the efficacy of new TB vaccines remains to be clarified as most participants included in trials ...
Efficacy of BCG vaccination in prevention of cancer: an update. J Natl Cancer Inst. 1978;60(4):785-788. doi:10.1093/jnci/60.4.785PubMedGoogle ScholarCrossref 7. Kendrick MA, Comstock GW. BCG vaccination and the subsequent development of cancer in humans. J Natl Cancer Inst. 1981;66(...
BCG is a potent immunomodulator, especially of the cell-mediated immunity, and is employed for the treatment of cancers such as that of the bladder30. It is actually being tested for several other cancers31. Recently, BCG was shown to exhibit efficacy against type I diabetes32. This was ...
Opinions on Treatment Split for Prominent Questions in Bladder Cancer Unmet Needs and Future Perspective in the Frontline Management of mRCC Balancing Efficacy Outcomes With Tolerability and Quality of Life in First-Line mRCC Treatment Decisions AI Tools for Accurate Cancer Diagnosis and Tailored Treatm...
He noted that this definition helps frame future treatment decision making for these patients as further BCG shows a lack of significant efficacy in these patients and instead increases their risk of progression. “This is of particular relevance in the current era that we’re talking about of th...