梅奥诊所联合33个医疗中心,开展了一项关于BCG治疗无响应的膀胱癌治疗新方案——Nadofaragene firadenovec基因疗法。Nadofaragene firadenovec,又称rAd-IFNa/Syn3,是一种复制缺陷型重组腺病毒,可将人干扰素α-2b cDNA递送至膀胱上皮细胞,为BCG无响应的非肌层浸润性膀胱癌患者提供了膀胱内新型疗法,其研究结果于2020...
At each visit, patients underwent an evaluation and physical examination to identify any AEs with endoscopic evaluation at week 17 and every 8 weeks until the completion of the trial at week 52 (last cystoscopy on week 49). ...
Cystoscopy schedule Cystoscopy +/- TURBT was done every three monthly for the first two years, then every six monthly for the next two years, then annually thereafter. If recurrence occurs then the clock for cystoscopy is re-set at every three months. Definitions of BCG responses BCG resistanc...
The schedule and the duration w as the one described by Lamm (induction therapy with weekly instillations of BCG under local anaesthesia, total 6 weeks; first one performed after 3 weeks of TURB, followed by cystoscopy after 6 weeks; a total maintenance for 36 weeks). The clinical controls ...
Natural language processing (NLP) was used to identify TURBT pathology reports, using the search term bladder, as well as other key words indicative of a TURBT, including transurethral and cystoscopy. The TURBT pathology reports were categorized as benign or malignant based on a combination of ...
Response to salvage therapies after BCG are highly dependent on pattern of tumour recurrence after BCG, especially with regards to dose, duration, and schedule of BCG administration and timing of tumour recurrence after BCG therapy For a patient to be considered BCG-unresponsive, they must have rec...
关键词: Humans Cystoscopy Combined Modality Therapy Drug Administration Schedule Questionnaires Hospitals, University Urinary Bladder Neoplasms Administration, Intravesical BCG Vaccine Time Factors DOI: 10.1021/ac801483d 年份: 1993 收藏 引用 批量引用 报错 分享 ...
The patients were followed every 3 months for the first year, every 6 months for the second year and every 12 months thereafter by cystoscopy and urine cytology. Recurrence was defined as the appearance of a tumour once the treatment has begun, with at least one tumour- free cystoscopy and ...
71/74 underwent two-year cystoscopy, and 66/71 (93%) remained recurrence-free. 30 patients (28%) did not complete the full induction schedule. Of these, 16/30 had minor schedule alterations and 14/30 had major alterations. There was no difference in recurrence between patients who received...
Thirty-eight (95%) of the 40 patients showed persistent negative post-treatment cystoscopy and cytology 6 months after Gem treatment, while the remaining 2 patients relapsed at 5 and 6 months. At a median follow-up of 28 months, recurrences had occurred in 14 patients. Among these, four ...