the bax inhibitor mrbi-1 regulates heat tolerance, apoptotic-like cell death, and virulence in metarhizium robertsii:bax抑制剂mrbi-1调节热耐受,凋亡样细胞死亡,并在robertsii绿僵菌毒力 热度: 金属硫蛋白在抑制糖尿病心肌病中内质网应激介导心肌细胞凋亡中作用的研究 ...
Our results uncover a new role for Bax Inhibitor-One (BI-1), a negative regulator of inositol-requiring enzyme 1 (IRE1α) in preserving β-cell health against terminal UPR-induced apoptosis and pyroptosis in the context of supraphysiological loads of insulin production. BI-1-deficient mice ...
The Bax inhibitor MrBI-1 regulates heat tolerance, apoptotic-like cell death, and virulence in Metarhizium robertsii[J]. Scientific Reports, 2015, 5: 10625.Chen, Y., Duan, Z., Chen, P., Shang, Y. & Wang, C. The Bax inhibitor MrBI-1 regulates heat tolerance, apoptotic-like cell ...
Keywords: idiopathic pulmonary fibrosis; BI-1; epithelial—mesenchymal transition; ER stress; lysosome; V-ATPase glycosylation Abbreviations: ER, endoplasmic reticulum; IPF, idiopathic pulmonary fibrosis; BI-1, Bax inhibitor-1; TGF, transforming growth factor; ECM, extracellular matrix; a-SMA, a-...
The Bax inhibitor-1 (BI-1) (also known as “testis enhanced gene transcript” (TEGT)) is an antiapoptotic protein capable of inhibiting Bax activation and translocation to mitochondria (7). This ubiquitously expressed protein contains several transmembrane domains and localizes to the ER. The hom...
The overexpression of Bax inhibitor-1 (BI-1) in prostate carcinoma and prostate cancer cell lines was confirmed by using Northern blot and Western blot analyses. Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) on intact RNAs from 17 paired laser-captured micro...
Bax inhibitor-1 (BI-1), an evolutionarily conserved protein, is a suppressor of cell death induced by the proapoptotic protein Bax and is involved in the response to biotic and abiotic stress in animals, plants and yeast. Rice false smut caused by Ustilaginoidea virens is one of the destruct...
Many proteins bearing this motif have been identified and incorporated into the public databases including three novel antiapoptotic proteins, Bax Inhibitor-1 (BI-1), Lifeguard (LFG), and h-GAAP. It has been proposed that BI-1 and LFG and probably other closely related proteins represent a new...
OPEN SUBJECT AREAS: CHEMOTHERAPY CALCIUM SIGNALLING Received 5 November 2013 Accepted 20 May 2014 Published 5 June 2014 Bax Inhibitor-1-Mediated Inhibition of Mitochondrial Ca21 Intake Regulates Mitochondrial Permeability Transition Pore Opening and Cell Death Geum-Hwa Lee1, Hwa-Young Lee1, Bo Li1,...
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid molecules complementary thereto (SEQ ID NO: 2 and SEQ ID NO: 5, respectively), portions of ...