Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons. Neuroreport - Martinou, Missotten, et al. - 1998 () Citation Context ...sent the point at which cells become committed to die (Deshmukh et al., 1996). Consistent with this, caspase inhibitors can ...
In addition, the expression levels of target genes and proteins were detected by real-time fluorescence quantitative PCR (RT-qPCR) and Western Blot. The results showed that knockout Bak and Bax inhibited erastin-induced ferroptosis significantly, and the expression levels of nuclear factor-erythroid ...
Bai M, Skyrlas A, Agnantis NJ,et al,Diffuse large B-cell lymphomas with germinal center B-cell-like differentiation immunophenotypic profile are associated with high apoptotic index, high expression of the proapoptotic proteins bax, bak and bid and low expression of the antiapoptotic protein bcl...
Proapoptotic BAX and BAK proteins form stable protein-permeable pores of tunable size J. Biol. Chem., 288 (2013), pp. 33241-33252 CrossrefView in ScopusGoogle Scholar Bleicken et al., 2013b S. Bleicken, C. Wagner, A.J. García-Sáez Mechanistic differences in the membrane activity of ...
(BOK) possesses three BCL-2 homology domains and has been proposed to act in a similar pro-apoptotic pathway as the pro-apoptotic proteins BAX and BAK. In this study, we showed that stage II and III colorectal cancer patients possessed decreased levels of BOK protein in their tumours ...
Background: During apoptosis Bax/Bak release differently sized proteins out of the mitochondria. Results: The size of Bax/Bak pores depends on protein concentration. Conclusion: Bax/Bak form stable toroidal pores tunable in size. Significance: Pore size-tuning constitutes a new level for the regula...
8、( 又称抗凋亡蛋白,antiapoptotic proteins) 有 Bcl-2 、 Bcl xL、 Bc1-w、 ced-9 等,促凋亡成员 ( 又称凋亡前体蛋白,Proapoptotic proteins) 有 Bad、 Bax、 Bak、 Bid 、 Bik 、 Bim、Bcl-xs等。促凋亡成员又分为两类:仅含BH3IW源区域(BH3 only Proreins)的成员,包括Bik ,Bid, Bad, Bim, ...
Bcl-2 family proteins are potent regulators of programmed cell death. Although their intracellular localization to mitochondria and the endoplasmic reticulum has focused research on these organelles, how they function remains unknown. Two members of the
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide... D Ren,HC Tu,H Kim,... - 《Science》 被引量: 676发表: 2010年 Bax- and Bak-induced cell death in the fission yeast Schizoaccha...
Notably, expression of Bcl-2 prevented not only the oligomerization of Bax and Bak, but also the association between these two proteins in energy-deprived cells. Using Bax-deficient HCT116 and BMK cells, we show that there is stringent Bax requirement for Bak homo-oligomerization and for ...