Evaluates dual-plate overpressured layer chromatography (OPLC) method for broad-scale screening of basic drugs in autopsy urine samples. Drug screening procedure of OPLC; Detection limits for drug substances in urine by OPLC with ultraviolet scanning densitometry; Comparison of drug identification by ...
mum sample volume needed to screen for a reasonably large proportion of the potential doping agents that are currently avail- able would probably exceed the volume that is typically sup- plied to the laboratory for analysis and, moreover, the demand ...
Quantitative aspects of the method were investigated for guanethidine and its metabolites, and a linear relationship was obtained between the peak area due to each of these compounds and the amount added to drug-free urine in the range of 1–20 μg/ml....
P. et al. Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen. Nat. Commun. 10, 2674 (2019). Article PubMed PubMed Central Google Scholar Carvalho, D. M. et al. Repurposing vandetanib plus everolimus for the treatment of ACVR1-...
drug candidates, such as duramycin, ivermectin, and azithromycin.14,206High-throughput drug screening is usually performed on intestinal organoids. For example, Kenji Kozuka et al. cultured mini colonic organoids in 96-well plates and performed a successful screen of approximately 2000 compounds for...
DrugCombDB: http://drugcombdb.denglab.org/ FDC: https://curate.ccr.cancer.gov/ GDC: https://gdc.cancer.gov/ GENIE: https://www.aacr.org/professionals/research/aacr-project-genie GEO: https://www.ncbi.nlm.nih.gov/geo Human Protein Atlas: https://www.proteinatlas.org/humanproteome/pat...
Careful characterization and standardization of the composition of plant-derived food supplements is essential to establish a cause-effect relationship between the intake of that product and its health effect. In this review we follow a specific grape se
As expected, tumor cells require more polyamines than normal cells to meet the demands for sustaining rapid growth, which is reflected in the increased levels of polyamines in urine or blood sample in cancer patients when compared to healthy individuals [93]. Dysregulation of polyamine metabolism ...
•Commonly requested haematological test profiles include full blood count, differential white cell count, erythrocyte sedimentation rate (ESR), serum folate and vitamin B12and iron status, and clotting screen. •Drug therapy can cause abnormal test results. ...
Biomarker screen, assay validation (see Figure 2B) Increased the capability to measure total arsenic and arsenic metabolites in blood, where concentrations are an order of magnitude lower than those in urine. Blood arsenic is a sensitive biomarker of arsenic exposure and is directly associated with ...