The transcription process starts with a pre-initiation complex (PIC), its activation and promoter clearance. Activation involves chromatin looping, usually promoted by the large multiprotein Mediator complex. R
3.1.4Basic leucine zipper transcription factor (BATF) BATF is abasic leucine zipper transcription factorthat belongs to the activator protein-1 (AP-1) family (Echlin et al., 2000). Researches have demonstrated that BATF is critical for the generation of Th17 as well asTfh cells, whereas ...
DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factor(s) to DNA. During development, the pattern of DNA methylation in the genome changes as a result of a dynamic process involving both de novo DNA ...
It exists in an open, decompacted confirmation, favoring active transcription or “poised” for gene expression. Heterochromatin refers to the “inactive” regions of the genome existing in a closed, highly compacted state. It contributes to the great majority of the genome; and comprises of non...
The basic helix-loop-helix (bHLH) transcription factors (TFs) play important roles in regulating multiple biological processes in plants. However, there are few reports about the function of bHLHs in flower senescence. In this study, a bHLH TF, PhFBH4, w
This section describes the process of developing basic capabilities of HUAWEI Push Kit so that you can send messages to Huawei phones. The following figure shows the process. Steps 1 and 2: An app integrated with the HMS SDK calls the HmsInstanceId.getToken method to obtain a push token. ...
The discovery of induced pluripotent stem cells changed the field of regenerative medicine and inspired the technological development of direct reprogramming or the process by which one cell type is directly converted into another without reverting a stem cell state by overexpressing lineage-specific ...
Development of ESCC ESCC develops via a multistep process that begins with a normal squamous epithelium and progresses to low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN), and ultimately to invasive carcinoma (Figure 3A).53 LGIN, HGIN, and invasive ESCC can...
(Eichberg & Iyer, 1996) suggests this post-translational modification might influence the close apposition of the cytoplasmicfacesof the membrane. (Whether phosphorylation modifies this process in a dynamic manner is a topic of speculation.) The physiological significance of the heterogeneity of MBPs, ...
A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644–648 (2005). This compendium analysis across 132 gene expression datasets representing 10,486 microarray experiments identifies ERG and ETV1 fused with TMPRSS2 as highly expressed genes...