In accordance with the 3R principle, we did not investigate additional controls, such as Gnai2+/+; LysM-Cre+/tg or Gnai2fl/+; LysM-Cre+/tg mice. C57BL/6N mice receiving antibody treatment (wtIgG or wtab) were obtained from Charles River (Wilmington, MA, USA). Mice of either sex...
S.No.ClassMethodPrincipleFeaturesLimitations 1. Profiling Whole Genome Methylation (Target genes are not known) HPLC-UV (high performance liquid chromatography-ultraviolet)[4,44] Hydrolysis of DNA into its constituent nucleoside bases, chromatographic separation of 5 mC and dC bases, measurement of frac...
No general principle has been developed to solve the transformation problem. This paper intends to systematically analyze the differences between the AC and NPV approach and its consequences for mo...E. Luciano, L. Peccati, Some basic problems in inventory theory: The "nancial perspective. XV ...
In principle, it is feasible to print arrays composed of virtually all annotated proteins of a given organism, effectively comprising a whole-proteome microarray. Functional protein microarrays have been successfully applied to identify protein–protein, protein–lipid, protein–antibody, protein–small ...
Overexpression of basic fibroblast growth factor (FGF-2) in transgenic (TgFGF2) mice results in a chondrodysplasia as the principle phenotype. Here we report a second phenotype in TgFGF2 mice that was previously undetected: A predisposition to angiogenic reactions with subsequent amplified ...
In principle, CSF, which communicates without barriers with the extracellular space of the central nervous system (CNS), i.e., with the milieu surrounding the neurons and glial cells, seems to be suitable to reflect central nervous processes such as biochemical processes in the brain after trauma...
On psychological growth and vulnerability: Basic psychological need satisfaction and need frustration as a unifying principle Journal of Psychotherapy Integration, 23 (3) (2013), pp. 263-280, 10.1037/a0032359 View in ScopusGoogle Scholar Vansteenkiste et al., 2005 M. Vansteenkiste, M. Zhou, W...
J. Folkman Angiogenesis: an organizing principle for drug discovery? Nat. Rev. Drug Discov., 6 (2007), pp. 273-286 CrossrefView in ScopusGoogle Scholar 3 A. Beenken, M. Mohammadi The FGF family: biology, pathophysiology and therapy Nat. Rev. Drug Discov., 8 (2009), pp. 235-253 Cro...
No general principle has been developed to solve the transformation problem. This paper intends to systematically analyze the differences between the AC and NPV approach and its consequences for mo...
S.No.ClassMethodPrincipleFeaturesLimitations 1. Profiling Whole Genome Methylation (Target genes are not known) HPLC-UV (high performance liquid chromatography-ultraviolet)[4,44] Hydrolysis of DNA into its constituent nucleoside bases, chromatographic separation of 5 mC and dC bases, measurement of frac...