The current review focuses on the role of subcortical dopamine dysfunction in psychosis and schizophrenia. We present and discuss alternative phenotypes that may provide a more translational approach to assess the neurobiology of positive symptoms in schizophrenia. Incorporation of recent clinical findings ...
Thomas G, Chung M, Cohen CJ (1985) A dihydropyridine (BAY k8644) that enhances calcium currents in guinea pig and calf myocardial cells. Circ Res 56:87–96 PubMed CAS Google Scholar Thomas G, Groß R, Pfitzer G, Rüegg JC (1985) The positive inotropic dihydropyridine BAY k8644 doe...
We now are aware that the functions of the cortex are determined by collective ehavior of neuronal ensembles, rather than by independent actions of single neurons. But, 40 years ago scientists were obsessed by an opposite view, suggesting that only behavior of single neurons would give a clue ...
further compounding frustrations. Overall, while Kldigi7777 has potential with its engaging platform, the recurring themes of service reliability and transparency issues need addressing to foster a morepositive user experience. This combination of
This protein may have yet other functions. Myelin basic proteins The major basic protein (MBP) of myelin has long been of interest because it was the initial myelin antigen that, when injected into an animal, elicited a cellular immune response that produced the CNS autoimmune disease called ...
Overall, this increases the permeability of the membrane to Na+ relative to that to K+ and, since ENa (the equilibrium potential for sodium) is positive, this tends to depolarize the cell (Section 1.4). IPSPs are generated in response to the inhibitory transmitter glycine as the result of ...
Accordingly, BAF complexes have been demon- strated to directly interact with numerous transcription factors, oftentimes in a tissue-specific manner, thereby allowing complex subunits to acquire context-dependent, and cell type-specific, functions that are ultimately dictated by their specific interacting...
The most significant changes observed in the 15 PCW old fetus are an increase in the overall number of synapses found in vertical probes of the cortex, the cortical plate does not contain synapses at any depth, the majority of synapses are found in the subplate, although the highest density...
This particle has the same properties as an electron except for its positive charge. When a positron enters the tissue, it travels only a few millimeters, depending on its energy (Table 1.1), before combining with an electron and emitting two gamma quanta, each having an energy of 511keV. ...
The article briefly summarizes neurocognitive findings that relate to mind-wandering and evidence regarding adverse effects of mind-wandering on task performance as well as evidence suggesting adaptive functions in regard to creative problem-solving, planning, resisting delay discounti...