СозданиеподключаемогомодуляИИдлясоединителя (предварительнаяверсия) Сертификациясоединителя Вопросыиответыопользовательскихсоединител...
Each panel is data for one patient. Symbols are observed drug concentrations, solid lines are the individual- predicted drug concentrations and dashed lines are the population-predicted drug concentrations. The LLOQ of the assay (0.05 ng/ml) is shown as a dashed black line. Each data set ...
At the beginning the goal was quite modest: to find a new functionally oriented method that would classify drug effects as alternative to structural methods based on chemical similarities between substances. During the last 50 years we faced a fast growth of studies in the field, foundation of ...
One-button operation, safe and convenient. The operation panel (touch screen/keypad) can set centrifugal speed, running time, heating temperature, and display real-time vacuum value and other parameters. ○ Homogeneous Flow Minimum sample volume of 15ml, especially suitable for expensive drug producti...
Cai S, Singh BR. Strategies to design inhibitors of Clostridium botulinum neurotoxins. Infect Disord-Drug Targ. 2007;7:47–57. CASGoogle Scholar Cai S, Kukreja R, Shoesmith S, Chang TW, Singh BR. Botulinum neurotoxin light chain refolds at endosomal pH for its translocation. Protein J. 200...
drug candidates, such as duramycin, ivermectin, and azithromycin.14,206High-throughput drug screening is usually performed on intestinal organoids. For example, Kenji Kozuka et al. cultured mini colonic organoids in 96-well plates and performed a successful screen of approximately 2000 compounds for...
(b) miRNA-like off-targeting of siRNA (for example, an siRNA targeting Renilla luciferase; siRL) caused by seed matches (Seed, left panel) or nucleation bulge sites (Nuc, middle panel) through transitional nucleation (base-pairs from position 2 to 6, red shade, right panel)26; pivot (...
For example, equilibrative nucleoside transporter-1 (ENT1) antagonists were found to be potent amplifiers of oHSV replication following a drug screening to identify molecules that increased viral spread [109], whilst a chemical library screen for compounds that sensitise cancer cells to viral ...
Recently, a screen of Food and Drug Administration-approved drugs identified L-type Ca2+ channel antagonists, the K+ATP channel opener minoxidil and the G(i) signaling activator clonidine, as inducers of autophagy, through a cyclical mTOR-independent pathway involving the regulation of IP3 concentrat...
Moreover, epigenetic-mod- ifying agents may couple with other standard chemo- therapeutic agents to boost clinical efficacy with lower doses of either drug. Emerging data indicate azacitidine and decitabine may modify multiple cellular pathways through gene reactivation, and sensitize cancer cells to ...