The concept of the blood-brain barrier derives from the classical studies of the pioneers in chemotherapy, such as Ehrlich, who administered dyestuffs parenterally in the hope that they would attack infective organisms. Thus Ehrlich observed that many dyes, after intravenous injection, stained the t...
The characterisation of amyloid-like aggregates in the seeds of the garden pea plant suggests that the amyloid form may also be utilised for protein storage in plants.26 The protein vicilin is present in protein bodies in an amyloid form and accumulates during maturation, where it is proposed ...
Fibre is composed of plant cell walls. Plant cell walls consist of complex carbohydrates such as polysaccharides, oligosaccharides, cellulose, hemicellulose, gums and pectins, which are embedded in a lignin matrix. Most of these molecules can be broken down and digested by caecal fermentation. Some...
Aquaporins are a group of proteins with high-selective permeability for water. A subgroup called aquaglyceroporins is also permeable to glycerol, urea and a few other solutes. Aquaporin function has mainly been studied in the brain, kidney, glands and skeletal muscle, while the information about ...
Current evidence supports the concept of carcinogenesis as a multistage process that is genetically regulated.3–6 The first step in this process is initiation, which requires exposure of normal cells to carcinogenic substances. These carcinogens produce genetic damage that, if not repaired, results ...
The oldest reference to the idea/concept of ‘principle of similars’ has been found in Ayurveda: Tadarthakari Chikitsa (treatment by similars) [34] where it is being mentioned three types of similarities: similarity of drug with the disease, similarity with the cause of the disease and the...
Over the last few decades, several anticancer agents, which are being investigated or used, belong to the plant world. This raises hopes for novel approaches used by CAM systems [1]. In connection with (cancer) research, one has to work as a humble instrument of God; both success as ...
More commonly used to measure the electrochemical potential difference between two points (e.g. either side of a cell membrane), thus sidestepping the rather abstract concept of a standard state. If the molecule is uncharged or the electrical potential difference between two points is zero, the ...
Plants can change their responses to future stressors when stressed, contributing to the concept of ‘stress memory’ [11,12,13]. As an adaptive mechanism, stress memory can increase resistance to stress factors, but it may also compromise aspects of the overall efficiency of the plant [14]....
These myofibroblasts also regulate the balance between MMP and tissue inhibitors of metalloproteinases (TIMPs), thereby facilitating the process of IPF [20]. 2.2. The Relationship between Silicosis and IPF 2.2.1. Cause of Disease The inhalation of free silica dust in the air is the main cause ...