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This indicates that the position of the nitro group at ortho and para positions enhances the activity rather than meta position. If we compared the o-fluoro substituted analog 18 (IC50 = 5.0 ± 0.1 µM) with m-fluoro analog 19 (IC50 = 10.5 ± 0.2 µM) and p-fluoro substituted ...
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All of these compounds contain different substituents at the para position to the imine group. The DPPH radical scavenging activity for this class is substantially lower than that of the first and second classes, but better than the standard antioxidant (BHT), due to their resonance-based ...
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