Base pair, in molecular biology, two complementary nitrogenous molecules that are connected by hydrogen bonds. Base pairs are found in double-stranded DNA and RNA, where the bonds between them connect the two strands, making the double-stranded structure
The meaning of BASE PAIR is one of the pairs of nucleotide bases on complementary strands of nucleic acid that consist of a purine on one strand joined to a pyrimidine on the other strand by hydrogen bonds holding together the two strands much like the r
The base‐pair sequences are the fundamental question for the biological process of DNA or RNA, in which base‐pair mismatch is very important to reveal genetic diseases and DNA rearrangements. The lack of well‐defined structural information about base‐pair mismatch is obstructing the investigation...
In the ternary substrate complex of DNA polymerase (pol) beta, the nascent base pair (templating and incoming nucleotides) is sandwiched between the duplex... WA Beard,DD Shock,SH Wilson - 《Journal of Biological Chemistry》 被引量: 131发表: 2004年 Nucleotide sequence of the FokI restriction-...
Scatter plot depicting the distance (x axis, log10 base pair (bp)) between rare hyper-mCpG tiles and closest rare A single nucleotide variant (SNV) (with minor allele frequency (MAF) < 0.5% based on gnomAD) and B structural variant (SV) (with MAF < 1% based on present study...
PCCRs represent regions in the pre-mRNA that have an increased capacity to base pair. The propensity of individual nucleotides to base pair was assessed at the transcriptome-wide level by measuring the nucleotide flexibility score with icSHAPE method41. We compared the average icSHAPE reactivity wit...
In theory,base callingon an Illumina instrument is a fairly simple process. After a single nucleotide is incorporated into the elongating DNA chain, the flow cell is scanned for each of the four bases and the base with the highest intensity is determined to be the incorporated nucleotide. In ...
US6673940 * Jan 6, 2000 Jan 6, 2004 California Institute Of Technology Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acidsUS6673940 2000年1月6日 2004年1月6日 California Institute Of Technology Compositions and...
Base-pairing interactions mediate many intermolecular target recognition events. Even a single base-pair mismatch can cause a substantial difference in activity but how such changes influence the target search kinetics in vivo is unknown. Here, we use hi
Base pair disruption at site 2 governs the positioning of the superhelical apices; therefore, we expected site 2 to be a major Bal-31 and S1 nuclease cleavage site. Our results, however, showed that site 2 is only a preferred Bal-31 (Fig. 3d) and S1 nuclease (Fig. 3e) cleavage site...