Amino acid ester hydrolysisPd(II)pH-stat techniqueDFT calculationAmino acid esters (L) react with [Pd(Eten)(H 2 O) 2 ] 2+ (Eten= N -ethyl ethylenediamine) giving mixed ligand complexes of the type [Pd(Eten)L] 2+ . Base hydrolysis of [Pd(Eten)L] 2+ was studied by pH-stat ...
Hydrolysis of poly(ethylene terephthalate) fibers (intrinsic viscosity: 0.819 dL/g) using methanolic sodium methoxide was compared to that using aqueous sodium hydroxide. Weight and tenacity loss occurred more rapidly with methanolic NaOCH3. After the methanolic NaOCH3 treatment, the surface appeared ...
Hydrolysis was by specific acid-base catalysis. The initial product of etofibrate solvolysis at pH > 6 is the monoglycol ester of clofibric acid; at ... ER Garrett,MR Gardner - 《Journal of Pharmaceutical Sciences》 被引量: 22发表: 1982年 Effect of N-methylation of 2-carbamoylphenyl mesi...
Serine proteases (e.g. trypsin, thrombin, subtilisin) catalyse the hydrolysis of ester or amide substrates through an acyl-enzyme intermediate in which the hydroxyl group of the active serine side chain is acylated by the substrate as depicted on Fig. 6 (see e.g. [141]). The attack of ...
Designed Polypeptide Catalysts Protein DesignCatalyst DesignDesigned CatalystsCatalysis of Ester Hydrolysis Design of a Folded Polypeptide Catalyst for Ester HydrolysisThe HisH+-His PairReactivity According to the Brnsted EquationCooperative Nucleophilic and General-acid Catalysis in Ester HydrolysisWhy General-...
intheesterhydrolysis. ’ 。Mostoftheenzymemodels designedsofarcontainonereactioncenterinasuitable ligandenvironment . Th e crown eth er is generally re— gar ded as th e fi rst generation organ ism o f m i metic en- z yme becau se o f its recognition functi on of gu ests an d ...
catalyzed hydrolysis, values of knH2O/knD2O = 1.5-1.6, and β = 0.69 for reaction of p-NO2-Q-6 with quinuclidine derivatives, tertiary amine catalysis of ester hydrolysis (except for the most reactive 2,4-diNO2 substituted esters) is best ascribed to general base catalyzed attack of ...
formed by intramolecular dehydration of phthalic acid. Phthalic anhydride is a white solid. It is an important raw material in chemical industry, especially in the manufacture of plasticizer. Hydrolysis, alcoholysis and ammonolysis can occur, and anthraquinone d...
An assay has been devised to detect double-base lesions based on the fact that the phosphoester bond 3′ to a nuclesoside bearing the formamido lesion is resistant to hydrolysis by nuclease P1. The residual modified dinucleoside monophosphates obtained from a nuclease P1 (plus acid phosphatase...
Therefore, N-Mannich bases prodrugs could be an excellent strategy to enhance the delivery of the active compound due to the enhancement in water solubility as well as enhancement in lipophilicity. The rate of hydrolysis of N-Mannich bases is the same in plasma and in buffer since its ...