A base-catalyzed keto-enol tautomerism is proposed to be responsible for the observed deuterium exchange. This finding has been applied to the preparation of tritium-labeled diazepam in which only aromatic protons are labeled with tritium atoms. A tritium-labeled diazepam lacking tritium atoms at 1...
The rates of base-catalyzed hydrolysis of pseudo esters derived from γ-keto acids show strikingly poor sensitivity to the nature of the leaving group.1a The rates vary in the narrow range of about 12-fold as contrasted to a 103-fold spread of the corresponding benzoate esters. The results ...
sare found in thenucleic acids, namelycytosine(2-oxy-4-aminopyrimidine) which is present in both DNA andRNA,uracil(2,4-dioxypyrimidine) which is present in RNA but not in DNA andthymine(5-methyluracil) which is present in DNA but not in RNA. They all exhibit keto-enoltautomerism....
keto-enol tautomerismtautomeric equilibriumbase-catalyzedThe keto-enol tautomerization of chrysophanol anthrone was systematically investigated via a series of density functional theory computations using the M06-2X/6-31 + G(d,p) level of theory. Bulk solvent effects were taken into account ...
Base-Catalyzed Keto-Enol Tautomerism of DiazepamKeto-enol tautomerismDiazepamDeuterationSpecific tritium labelingJournal of the Chinese Chemical Society楊憲桂
keto-enol tautomerismtautomeric equilibriumbase-catalyzedThe keto-enol tautomerization of chrysophanol anthrone was systematically investigated via a series of density functional theory computations using the M06-2X/6-31 + G(d,p) level of theory. Bulk solvent effects were taken into account implicitly...
The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model ...
and Li,H. (2005) Base-pairing, tautomerism, and mismatch discrimination of 7-halogenated 7-deaza-20-deoxyisoguanosine: oligonucleotide duplexes with parallel and antiparallel chain orientation. J. Am. Chem. Soc., 127, 7739-7751.Seela, F., Peng, X., and Li, H. (2005) Base-pairing, ...
[4+2] like cycloaddition between DNA base group molecules and Si(111)7x7 surface preceeded by keto-enol tautomerismZhang, LChatterjee, ALeung, K T
Keto–enol tautomerism, acid- and base-catalyzed Acids and bases both bring about the establishment of an equilibrium between ketones (or aldehydes) and their enol forms, which contain a hydroxyl group directly attached to a doubly bonded carbon atom: The interconversion between the two forms is ...