The blood–brain barrier (BBB) prevents harmful toxins from entering brain but can also inhibit therapeutic molecules designed to treat neurodegenerative diseases. Focused ultrasound (FUS) combined with microbubbles can enhance permeability of BBB and is
Microbubbles (MBs) serve as a critical catalyst to amplify local cavitation in CNS capillary lumen to facilitate focused ultrasound (FUS) to transiently open the blood-brain barrier (BBB). However, limited understanding is available regarding the effect of different microbubbles to induce BBB opening...
All patients received bowel preparation with low-volume PEG-based bowel lavage in a split dose regimen. Colonoscopy was performed using commercially available HD endoscopes and video processors (EC38-i10 and Optivista EPK-i7010, both Pentax Medical, Tokyo, Japan). Care was taken to minimize sucti...
All efforts were made to minimize animal suffering, and animal care was supervised by veterinarians and animal technicians skilled in the healthcare and housing rodents and NHPs. Body temperature and respiratory rate were monitored throughout the experiments. All animal heads were shaved and covered...
At present, commercial- ized MBs include OptisonTM (GE Healthcare, WI, USA), Definity (Lantheus Medical Imaging, MA, USA), and SonoVue (Bracco, Milano, Italy), all with clinically approved for diagnostic purposes by the FDA. Commercial bubbles are generally larger than 2 μm...
The blood–brain barrier (BBB) plays a vital role in safeguarding the central nervous system by selectively controlling the movement of substances between the bloodstream and the brain, presenting a substantial obstacle for the administration of therapeutic agents to the brain. Recent breakthroughs in ...
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