Kidney Cancer Tandem Mass Spectrometry Omics Cell Adhesion* BAP1 Clear Cell Renal Cell Carcinoma Mesenchymal–Epithelial Transition Proteomics Snail BAP11 is a member of the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes (DUBs) (1). Histone H2A (Lys119) was the first identified...
Kidney renal clear cell carcinoma (KIRC) is the predominant pathological subtype of kidney cancer and is categorized as immunotherapy responsive. Hence, immunotherapy has become a worthwhile therapy for KIRC. Furthermore, tumor mutation burden (TMB) has been regarded as the most prevalent biomarker ...
BRCA1-associated protein 1 (BAP1) was originally identified as an interacting protein of Breast cancer type 1 susceptibility protein (BRCA1). BAP1 is mainly localized in the nucleus and exerts tumor suppressive effects by binding to the RING finger domain of BRCA1 [1]. As a ubiquitin carboxy...
it will be worth to investigate whether these processes act in concert or independently during cancer development. It is possible that, depending on the cellular context and the stages of malignant transformation, BAP1 might mandate one or both of these processes. BAP1 and p53 are possibly the ...
The roles and regulatory mechanisms of ferroptosis (a non-apoptotic form of cell death) in cancer remain unclear. The tumour suppressor BRCA1-associated protein 1 (BAP1) encodes a nuclear deubiquitinating enzyme to reduce histone 2A ubiquitination (H2Aub) on chromatin. Here, integrated transcriptomic...
SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells with high overexpression of SLC7A11 in combination with H2O2treatment results in toxic buildup of intracellular cystine and other disulfide molecules, NADPH depletion, redox system collapse, and rapid cell death...
(BAP1) in cancer and placentation. Initially recognized for its tumor-suppressive properties, BAP1 has emerged as a key regulator at the intersection of tumorigenesis and placental development. BAP1 influences crucial cellular processes such as cell death, proliferation, metabolism, and response to ...
How the BAP1 multi-protein complexes are assembled and structured in various cellular contexts and in response to stress? Does BAP1 deficiency creates targetable vulnerabilities for cancer treatment? Introduction BAP1 is a widely expressed deubiquitinase (DUB) that belongs to the ubiquitin C-terminal ...
In Madine Darby canine kidney (MDCK) cells, MAGI-1/BAP1 was colocalized with ZO-1, whereas SAP97/hDLG was colocalized with E-cadherin. In MDCK cells, dominant active and negative mutants of Rac1 small G protein changed the amounts of SAP97/hDLG at cell – cell junctions, but ...
In this proof-of-concept study, we performed a detailed correlative analysis of the mutational and immunological landscapes in a series of 23 consecutive kidney cancer patients. We discovered that a high infiltration with CD8+T cells was not dependent on the number of driver mutations but rather ...