Balancing biochemical equations for both mass and charge in metabolic networks is critical but unfortunately ignored too often. Failure to do so, for example, results in a common misconception about the origin of protons during lactic fermentation. Lactate, rather than lactic acid, is produced by ...
the equation using trial and error. This may mean it requires too many steps and the chemical equation is too complex to use this method, or that the equation is invalid (e.g. has 0 or non-integer coefficients). The algebraic method is likely better suite...
The biological fitness of microbes is largely determined by the rate with which they replicate their biomass composition. Mathematical models that maximize this balanced growth rate while accounting for mass conservation, reaction kinetics, and limits on
Although balanced with regard to essential nutrients, the cereal based diets varied widely in chemical composition and accounted for 90% of the variation in the chemical composition of the diets used in practice. The pigs were distributed on dietary treatments on a within-litter basis taking sex ...
In recent years, constraint-based metabolic models have emerged as an important tool for metabolic engineering; a number of computational algorithms have been developed for identifying metabolic engineering strategies where the production of the desired chemical is coupled with the growth of the organism...
In recent years, constraint-based metabolic models have emerged as an important tool for metabolic engineering; a number of computational algorithms have been developed for identifying metabolic engineering strategies where the production of the desired chemical is coupled with the growth of the organism...