We previously identified the Bcl-2-associated death promoter (BAD) as a prognostic indicator of good outcome in taxane-treated breast cancer patients. We also demonstrated that BAD expression in human breast carcinoma cells generated larger tumors in mouse xenograft models. These paradoxical results ...
Be very clear about the data you’re providing, and be even more clear about how you expect the results to be presented. You’ll notice that sometimes I repeated numbers (like the volume of the ark) in subsequent prompts, even though we’d already calculated this value much earlier. In ...
This is likely to have introduced selection bias resulting in lower effectiveness and a higher SAE rate in the eligible adalimumab patients, and therefore an underestimation of the gap between the 2 populations in our results for adalimumab. However, reporting standards of clinical trials having ...
Results showed a -0.64 mg/dL and a -3.14 mg/dL reduction in HDL-cholesterol ("good" cholesterol) and LDL cholesterol ("bad" cholesterol), respectively, in the fortified egg group. While these differences weren't statistically significant, the researchers said the differences suggest that eating ...
I accept the results thought experiment (ignoring the other issues with those calculations, including the issues with using this sort of calculation in the first place), but it (or anything similar) seems to be virtually unheard of in real life. I don't think even people who feel like they...
is present in BAT-SL-CoVZC45. The ARKS motif is a PTM site critical to histone H3 at lysine 9 and lysine 27 (H3K9 and H3K27) [210]. Kee and colleagues demonstrated that the histone mimic ORF8 disrupts chromatin accessibility and results in significant differences in gene expression [210...
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(2007) based on the results of feeding experiments with isotopically labelled predicted intermediates. Total synthesis has been achieved, so far adopting three different strategies, as reviewed by Fazakerley and Procter (Fazakerley & Procter 2014), however so far these have always resulted in low pro...
Results BAD pathway expression associates with triple-negative status and overall survival To evaluate the overall expression and activation of the BAD pathway in breast cancer, PCA was used to generate a BPGES score. The genes comprising the BPGES included BAX, BCL-2, EGFR, PDK1, PIK3CA, PIK...
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