Mechanism Of Action Mupirocin is an RNA synthetase inhibitor antibacterial [seeMicrobiology]. Pharmacokinetics Absorption Systemic absorption of mupirocin through intact human skin is minimal. The systemic absorption of mupirocin was studied following application of BACTROBAN cream 3 times daily for 5 days ...
12.1 Mechanism of Action Mupirocin is an RNA synthetase inhibitor antibacterial [see Microbiology (12.4)]. 12.3 Pharmacokinetics Absorption Following single or repeated intranasal applications of 0.2 grams of BACTROBAN nasal ointment 3 times daily for 3 days to 5 healthy adult male subjects, no evide...
12.1 Mechanism of Action Mupirocin is an RNA synthetase inhibitor antibacterial [see Microbiology (12.4)]. 12.3 Pharmacokinetics Absorption Systemic absorption of mupirocin through intact human skin is minimal. The systemic absorption of mupirocin was studied following application of BACTROBAN cream 3 time...
Mechanism of Resistance Low-level resistance in staphylococci is thought to result from point mutations within the usual staphylococcal chromosomal gene (ileS) for the target isoleucyl tRNA synthetase enzyme. High-level resistance in staphylococci has been shown to be due to a distinct, plasmid enc...
of a left arm positioned before a topic whose actual left arm was hidden by a screen. Using two small brushes, the experimenters synchronously stroked corresponding positions of the rubber and actual arm. All these phenomena show how labile the perceived location of a stimulation may be, and ...
Mechanism of Action Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer‑RNA (tRNA) synthetase. Mupirocin is bactericidal at concentrations achieved by topical intranasal administration. Mupirocin is highly protein bound (>97%), and the effe...