over the past 25 years it has been shown that gram-positive bacteria are the most common cause of sepsis [103]. Some of the most frequently isolated bacteria in sepsis areStaphylococcus aureus(S. aureus),Streptococcus
Streptococcus agalactiae, also known as Group BStreptococcus(GBS) is an opportunistic pathogen of humans and animals, which causes a diverse range of infections that encompasses asymptomatic colonization and severe and life-threatening systemic disease such as toxic shock-like syndrome1. GBS is the wor...
Capsules are crucial in bacterial invasive infections, acting as an energy-consuming virulence factor. Bacteria frequently utilize carbohydrates via glycolysis and other central carbon metabolism (CCM) to support the energy demands of capsule synthesis104. CCM encompasses enzymatic reactions converting carbon...
The importance of capsules in bacterial pathogenesis is also demonstrated by the dominant roles of encapsulated bacteria in sepsis, which is a common and complex syndrome resulting from microbial infections with acute organ dysfunction and a high risk of death [265]. Encapsulated bacteria are the ...
The bacterial organisms are usually not confined to the brain and meninges and frequently causesystemic illness– for example, severesepsis,shock,acute respiratory distress syndrome, and bleeding disorders such asdisseminated intravascular coagulation.2,3 ...
tumor reduction; instead, they often resulted in mild side effects and successful bacterial colonization in patients. The collective experience from clinical trials indicates that although modified bacteria may demonstrate reduced virulence, they frequently fall short of delivering the intended therapeutic ...
During injury, the shrapnel damages tearing flesh, breaking bones, and usually causes pointed irregular wounds and causes unavoidable sepsis [8], and becomes a serious global cause of morbidity and mortality [9]. Antibiotics are commonly used immediately upon arrival to the health institution to ...
Compared with other antibacterials, linezolid is associated with a greater frequency of adverse events, mainly nausea, vomiting, diarrhoea and headaches. Thrombocytopenia also occurs more frequently in patients taking linezolid but there is no increased frequency of anaemia. Other adverse events potentially...
In this device, bacterial cells are lysed using an external voltage, which causes the release of enzymes like β-lactamase. The reaction of these enzymes with nitrocefin in a nanoporous membrane causes the nitrocefin patch to change its color from orange to red. Thus, enzymes causing ...
Finally, the method with the most discriminatory power is whole-genome sequencing, which allows all genomic differences between clinical isolates to be identified. strains belonging to clonal types are frequently found in the nasopharynx, and are therefore associated with car- riage and opportunistic ...