Central to an understanding of the structure-function relationships of these various bacterial membrane systems are (1) resolution of the complexity of the components in plasma membranes, outer membranes of gram-negative bacteria, and specialized membranes such as chromatophores, and (2) establishment ...
The arrangement of these molecules is, however, not random, but regulated (in the physiological state) or dysregulated (in a disease state), which affects the coexistence, movement, trafficking and function of each component and of the entire membrane. Alterations to cell membrane dynamics and ...
Bacterial membranes: structure, domains, and function. Annu. Rev. Microbiol. 71, 519–538 (2017). CAS Google Scholar Gunasinghe, S. D. et al. The WD40 protein BamB mediates coupling of BAM complexes into assembly precincts in the bacterial outer membrane. Cell Rep. 23, 2782–2794 (...
Structure and function of SecA, the preprotein translocase nanomotor Most secretory proteins that are destined for the periplasm or the outer membrane are exported through the bacterial plasma membrane by the Sec translocase... E Vrontou,A Economou - 《Biochimica Et Biophysica Acta Molecular Cell ...
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture ZO-2 is a tight junction (TJ) protein that shuttles between the plasma membrane and the nucleus. ZO-2 contains several protein binding sites that allow it...
Theouter membraneof Gram-negative bacteria plays a key role in bile resistance, which requires the expression and function of multipleOMPs. In general, these OMPs either affect themembrane permeability(e.g. porins) tobile salts, or are involved in the efflux of these antimicrobial detergents. Por...
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The heterologously expressed H+-PPases are distributed among different yeast membranes, including the plasma membrane, functional complementation by these integral membrane proteins being consistently sensitive to external pH. These results demonstrate that hydrolysis of cytosolic PPiis essential for yeast ...
We report that gram-negative bacterial LPS binds to discrete domains of the human monocyte-macrophage (THP-1 cell) plasma membrane (PM). PM fragments were separated on density gradients after gentle cell disruption using a detergent-free method. The LPS-binding fragments had a low bouyant density...
(DCs), essential for antigen recognition and presentation, are typically dysfunctional and rare in TME19,20. Moreover, antigens cannot cross through the tumor stroma and may be quickly cleared by the tumor tissues21. Recruiting more DCs and restoring their function by immune factors or activators...