Prosthetic joint infection is a severe complication of arthroplasties, requiring effective prevention and osteoinduction strategies. Here, a bilayer coating system with antibiotics for infection prevention and
Leishmaniasis, the subsequent degree of infection is determined by the cell-mediated response of the infected person. Demonstration of the parasite in peripheral blood smears, ascitic fluid, or biopsy of the bone marrow, spleen, or liver establishes the diagnosis. Sodium stibogluconate, amphotericin...
2. Endogenous-stimuli-mediated nanocatalytic medicine anti-infection 3. External stimuli-responsive nanocatalytic medicine anti-infection 4. Catalysis-assisted immunotherapy (CAIT) 5. Conclusion and perspective Availability of data and materials Ethics approval and consent to participate Consent for publication...
The immune system has evolved to fight off microbial invasion through the coordinated action of the innate and adaptive arms of the immunity. Innate immune cells respond to a variety of stimuli, including bacterial, viral, parasitic or fungal infections, via members of structurally related receptors ...
21 Therefore, relying on conventional antibiotics or bactericidal biomaterials alone is no longer sufficient to treat multidrug-resistant bacterial infections. Therapy with a direct antimicrobial and synergistic effect on immune cells is required. Over the past decade, the use of immunomodulatory agents ...
Animal holobionts constitute diverse yet interconnected landscapes of microenvironments that harbor specific bacterial communities with distinct functions.
Although the condition is self-limiting, it can impact the delivery of optimal cancer treatment, since it is associated with clinically significant pain, compromised nutrition, prolonged hospitalization, bloodstream infections and antineoplastic dose reductions [3, 4]. Different approaches to prevent or ...
Infection remains a major cause of morbidity and mortality, regardless of advances in antimicrobial therapy and improved knowledge of microorganisms. With the major global threat posed by antimicrobial resistance, fast and accurate diagnosis of infection
Further studies are required to resolve this issue of transient and true colonization. The overuse of antibiotics altered mycobiota induces fungal overgrowth and infection. 4.2 Virobiota The virus load in the gut is equivalent to the bacterial cells but the viruses outnumber the bacteria on mucus...
Immune suppression can be reversed by inhibiting the local interaction of PD-1 with PD-L1 or PD-L2; the effect is additive when the interaction of PD-1 with both PD-L1 and PD-L2 is blocked. The PD-1 pathway can be exploited in cancer or infection, whereby tumours or viruses can ...