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Rapid Detection of Bacteria in Blood for the Early Diagnosis of SepsisSachidevi Puttaswamy
The presence of bacteria in the blood is called bacteremia. When these bacteria rapidly multiply and release toxins in the blood, then the condition is called septicemia. Bacteria may establish bloodstream infection or disseminate to infect internal organs and tissues. So, in the blood of infected...
Blood stream infection or sepsis is a major health problem worldwide, with extremely high mortality, which is partly due to the inability to rapidly detect and identify bacteria in the early stages of infection. Here we present a new technology termed 'Integrated Comprehensive Droplet Digital Detect...
Blood culture samples were positive in 412 cases,the rest( 196 cases) were diagnosed according to clinical manifestations and laboratory tests. The composition ratio of sepsis during the first 4 years was significantly lower than that of the subsequent 4 years( 2. 58%,225 /9 805 vs. 2. 85...
Sepsis is treated with antibiotic drugs injected directly into the blood. One important drug group for sepsis treatment is called carbapenems. Carbapenems are often referred to as 'last-resort' drugs because they are some of the few that are effective against the increasing number of drug-resista...
Bacterial vaginosis (BV) is an enigmatic polymicrobial condition characterized by a depletion of health-associated Lactobacillus and an overgrowth of anaerobes. Importantly, BV is linked to adverse gynecologic and obstetric outcomes: an increased risk of
For example, as one of the leading causes of sepsis is bacteraemia, a rapid method for the detection of viable bacteria in blood would enable the timely administration of antibacterial agents. This would help to reduce the prevalence of mortality associated with sepsis (10–20% fatality rate),...
Some organisms, such as Staphylococcus or Streptococcus, can cause skin infections, pneumonia, meningitis and even overwhelming sepsis, a systemic inflammatory response producing shock, massive vasodilation and death.[155] Yet these organisms are also part of the normal human flora and usually exist ...
gut-flora in humans, but it can also cause infection, such as intra-abdominal sepsis and bacteremia). InPseudomonas aeruginosasimilar vesicles have been shown to be involved in signalling (they carry quinolone signalling molecules involved inquorum sensing). ...