For naive B cells from 7 relapsing NMOSD patients, TLR9 ligand (CpG-ODN) synergized with IFN-纬 to enhance plasmablast formation in vitro. This was not found for 11 non-relapsing patients or 9 healthy controls. IFN-纬- and CpG-ODN-induced naive B cells showed increased IgG secretion ...
The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However, intravital imaging suggests that early
Ighb strains had larger numbers of PE-specific naive B cells and generated smaller germinal center responses and larger numbers of IgM memory cells than the Igha strain. The properties of PE-specific B cells in Ighb mice correlated with usage of a single VH that afforded high-affinity PE ...
什么是Naïve B cell 与T细胞类似,B细胞也是从干细胞分化而来,通过接触独特的抗原分化后激活。B细胞表面受体BCR与外来抗原结合后发挥下游生物学功能。通常来说,B细胞发育的最后阶段在脾脏中,在那里发育成初始B细胞。这些不被激活的初始B细胞随着血液进入到刺激淋巴器官(SLO)。初始的B细胞更容易捕获病原体,因为SLO的...
Seasonal influenza vaccination in humans primarily stimulates pre-existing memory B cells, which differentiate into a transient wave of circulating antibody-secreting plasmablasts1,2,3. This recall response contributes to ‘original antigenic sin’—the selective increase of antibody species elicited by ...
P Reichardt,B Dornbach,S Rong,S Beissert,M Gunzer 摘要: Naive B cells are ineffective antigen-presenting cells and are considered unable to activate naive T cells. However, antigen-specific contact of these cells leads to stable cell pairs that remain associated over hours in vivo. The ...
The IFN-λ1-induced pSTAT1 level is slightly higher in naive B cells compared with CD27+ memory B cells (Figure S1F). A JAK inhibitor assay was used to confirm that IFN-λ signals through the JAK-STAT pathway: the JAK inhibitor (3 μM ruxolitinib) almost blocked IFN-α2- or IFN-...
Tangye, Naive and memory B cells exhibit distinct biochemical responses following BCR engagement. Immunol Cell Biol, 2016. 94(8): p. 774-86.Moens L, Kane A, Tangye SG. Naive and memory B cells exhibit distinct biochemical responses following BCR engagement. Immunol Cell Biol. (2016) 94:...
aThe ABCB1 Transporter is also used to differentiate Transitional B-cells from Naive B-cells. Dyes such as Rhodamine123 and MitoTracker Dyes from Invitrogen can be used to make this differentiation. ABCB1运输者也用于区分过渡B细胞从天真B细胞。 染料例如Rhodamine123和MitoTracker染料从Invitrogen可以用于...
摘要: Objectives To examine the expression of B-cell-activating factor receptor (BAFF-R) on naive CD27− and memory CD27+ B cells in normal individuals and patients with rheumatoid arthritis (RA) undergoing B-cell depletion therapy with rituximab....