The metabolite Pyridoxic Acid (PA) is excreted into the urine.Several acquired and genetic causes lead to vitamin B 6 deficiency manifesting in several neurological symptoms including seizures. The determination of the B 6 vitamers is especially important in the differential diagnosis of vitamin B 6...
Pyridoxine deficiency may lead to anaemia, dermatitis, cheilosis, and neurological symp- toms such as peripheral neuritis, and convulsions. Pyridoxine is used in the treatment and prevention of pyridoxine deficiency states. It is usually given orally, the preferred route, but may also be given by...
Importantly, no trial evaluated the risk of developing dementia, clinical symptoms, neurological imaging tests, or clinical outcomes beyond ability to perform cognitive function tests. About 50 different tests or subtests were used across the trials, measuring different or overlapping domains of ...
Objectives: A controlled long-term study was performed to assess the neurological and neuropsychological performance in adult patients with early-treated p... J. Weglage a,J. Fromm b,A. van Teeffelen-Heithoff a,... - 《Molecular Genetics & Metabolism》 被引量: 53发表: 2013年 Cerebral glu...
Bacterial meningitis caused by Streptococcus pneumoniae leads to death in up to 30% of patients and leaves up to half of the survivors with neurological sequelae. The inflammatory host reaction initiates the induction of the kynurenine pathway and contributes to hippocampal apoptosis, a form of brain...
Huntington’s disease (HD) is an incurable and progressive neurodegenerative disease affecting the basal ganglia of the brain. HD is caused due to expansion of the polyglutamine tract in the protein Huntingtin resulting in aggregates. The increased PolyQ length results in aggregation of protein Huntin...
was financially supported by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) under Award Number T32NS048004 and the National Institute of Mental Health (NIMH) under Award Number K99MH116115. R.A.O. is supported by the National ...
B. Neurological symptoms C. Severe clinical immunodeficiency, resulting in opportunistic pathogen infections D. Secondary tumors due to immune deficiency, such as Carver’s sarcoma, non-Hodgkin’s disease, etc. 查看完整题目与答案 综合性装饰为拼贴式装饰和吊挂式装饰的组合,它可以使某一环境显得更...
B. Neurological symptoms C. Severe clinical immunodeficiency, resulting in opportunistic pathogen infections D. Secondary tumors due to immune deficiency, such as Carver’s sarcoma, non-Hodgkin’s disease, etc. 查看完整题目与答案 综合性装饰为拼贴式装饰和吊挂式装饰的组合,它可以使某一环境显得更...
Beyond its role as a cofactor for over 160 enzymes, B6 deficiency alters neurological functioning via depressed N-methyl-D-aspartate (NMDA) receptor function [145]. Medications such as isoniazid can also interfere with vitamin B6 metabolism. Isoniazid is used to treat tuberculosis but can lead to...