催化N-糖基化：有研究表明，b3GNT3能够催化PD-L1的N-糖基化。这种糖基化修饰能够增强PD-L1的稳定性，并可能通过影响其与GSK3β的相互作用来调节其降解过程。与肿瘤相关：b3GNT3被证实参与多种实体肿瘤的发生与发展，如宫颈癌、肺癌、胰腺癌、乳腺癌、非霍奇金淋巴瘤等。在胰腺癌中，b3GNT3的表达与肿瘤进展和...
这是一种重要的翻译后修饰方式,可以改变蛋白质的定位、稳定性和功能。 催化N-糖基化:有研究表明,b3GNT3能够催化PD-L1的N-糖基化。这种糖基化修饰能够增强PD-L1的稳定性,并可能通过影响其与GSK3β的相互作用来调节其降解过程。 与肿瘤相关:b3GNT3被证实参与多种实体肿瘤的发生与发展,如宫颈癌、肺癌、胰腺癌...
Li, Lim, Chung, Kim, Park, Yao, Cha, Xia, Chan, Kim, Chang, Lee, Chou, Liu, Yeh, Perillo, Dunn, Kuo, Khoo, Hsu, Wu, Hsu, Yamaguchi, Huang, Sahin, Hortobagyi, Yoo, Hung: "Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1." in:Cancer cell,Vol....
Identifying the prognostic significance of B3GNT3 with PD-L1 expression in lung adenocarcinoma. Authors - Xuefeng Leng View Article human WB,IHC PLoS One B3GNT3 Expression Is a Novel Marker Correlated with Pelvic Lymph Node Metastasis and Poor Clinical Outcome in Early-Stage Cervical Cancer. Author...