人白细胞抗原 G (Human leukocyte antigen G, HLA-G)是一种非经典的 HLA- I 类分子, 主要表达于胎盘的胞外滋养细胞,在妊娠期间介导母胎免疫耐受。虽然 HLA-G 在健康组 织中的表达受到限制,但病理条件可以诱导 HLA-G 的表达。在各种癌症中,已经观察到 HLA-G 的表达,包
Cell surface HLA-I molecules (Face-1) consist of a polypeptide heavy chain (HC) with two groove domains (G domain) and one constant domain (C-domain) as well as a light chain, B2-microglobulin (B2m). However, HCs can also independently emerge unfolded on the cell surface without peptide...