B27K-去B链C端三肽胰岛素2) monomeric destetrapeptide human insulin B链C端去四肽胰岛素 3) B25-Trp despentapeptide insulin amide 〔B25-Trp〕去B链C端五肽胰岛素酰胺4) Des-terpeptide of C-terminal human insulin 去B链羧端三肽人胰岛素
Metabolic potencies of the destetrapeptide insulin analogues des-(B27–B30)-insulin, des-(B27–B30)-insulin-B26-amide, [Thr B26 ] des-(B27–B30)-insulin-B26-amide and [Glu B26 ] des-(B27-B30)-insulin-B26-amide were studied in anaesthetized adult rats and in primary cultures of rat...
An insulin derivative or a physiologically tolerable salt thereof, in which asparagine in position B3 of the B chain is replaced by a naturally occurring basic amino acid residue and at least one amino acid residue in the positions B27, B28 or B29 of the B chain is replaced by another ...
Insulin controls hyperglycemia caused by diabetes,and virtually all treatments require exogenous insulin. The monomeric B27 Lys destripeptide insulin has 80% bioactivity of wild type. It is a potential drug for clinic. But the yield of monomeric B27 Lys destripeptide insulin is limited, because mono...
insulin, Asp(B9)-Glu(B27)-| 基本信息 更多信息 中文名称: 中文同义词: 英文名称: insulin, Asp(B9)-Glu(B27)- 英文同义词: insulin, Asp(B9)-Glu(B27)- CAS号: 110734-38-8 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览insulin, Asp(B9)-Glu(B27)-国外供应商 ...
阅读量: 11 作者: J Gibson 展开 摘要: The use of continuous subcutaneous insulin infusion (CSII) (i.e. insulin pump) therapy, continues to grow among patients with type 1 and type 2 diabetes increasing the li.. 展开 DOI: 10.4172/2167-1168.1000199 被引量: 2 年份: 2014 收藏...
1) monomeric B27 Lys destripeptide insulin B27 Lys DTrI 2) MAG_3-Lys-mPEG MAG3-Lys-mPEG 1. Starting with mPEG-5000,Fmoc-Lysine,and mercaptoacetyltriglycine(MAG_3),the carrier MAG_3-Lys-mPEG is synthesized through five steps,which carrier is labeled by ~(99)Tc~m with labeling effic...
Two analogs of bovine insulin, [des(tetrapeptide B27–30), Tyr(NH2)26-B] and [des(pentapeptide B26–30), Phe(NH2)25-B] insulin, which differ from the parent molecule in that the C-terminal tetrapeptide and pentapeptide sequences, respectively, from the B chain have been eliminated and ...
The objective of these experiments was to determine the relationship between insulin resistance and the onset of hyperphagia. Insulin tolerance tests showed that fatties were remarkably insulin resistant prior to the onset of hyperphagia, hyperinsulinemia, and obesity, but become as insulin sensitive as ...
Standard radioimmunoassay for insulin may substantially overestimate levels of insulin because of cross-reaction with other insulin-like molecules. We have measured concentrations of insulin, intact proinsulin and 32–33 split proinsulin using two-site monoclonal antibody based immunoradiometric assays, and ...