The pharmacodynamics (PD) of B16F10 tumor-bearing mice receiving microneedle delivered recombinant murine Interleukin-12 (rmIL-12) were evaluated against subcutaneous (SC) and intraperitoneal (IP) delivery. Microneedle delivery exhibited a significantly slower tumor growth curve, increased NK cell ...
23阳daythetumor-bearing feetwere surgically incisedandfixedin 1 0%formaldehyde for immunohitochemistryanalysis,theexpression of CD34,VEGF MMP2,MMP9 oftumortissuesweretestedtocharacterizetumor angiogenesis in tumortissue.Onthe 46协daymice were sacrifiedlungs ...
Besides, administered IL2-ADSCs significantly reduced systemic CD4+ cells and did not impact the total survival of lung metastases melanoma bearing mice. In conclusion, this study showed that IL2-producing ADSCs can favor B16F10 melanoma cell proliferation. Therefore, therapies utilizing IL2 have to...
mice. The tumor volumes were measured every 2 days from the fifth day to the fifteenth. After sacrifice of the mice, the tumor tissues were isolated for immunofluorescence (IF) or for isolation of TILs. (A) Representative tumor images of mice bearing ShCon and ShKALRN tumors. The gra...
This study was improved by several new approaches, like the use of IC50 index for cells viability, and the inclusion of ortho-phenantroline group of treated dorsal tumor bearing mice. A clear distinction between increased apoptosis or necrosis was achieved by jara or jari treatments, respectively...
Tumor growth of B16/IL18 in natural-killer- or CD8+ T-cell-depleted mice To characterize the cells responsible for the inhibition of tumor growth, tumor-bearing hosts were depleted in vivo in selected effector-cell populations. Depletion of CD8+ T cells by anti-CD8 mAb as well as natural ...
Hematoxylin/eosin-stained tumor sections from B16F10 melanoma-bearing mice.Fernanda, FaiãoFloresJosé, Agustín Quincoces SuarezAndréa, Costa FruetSilvya, Stuchi MariaEnglerPaulo, Celso PardiDurvanei, Augusto Maria
Biphasic effects of propranolol on tumour growth in B16F10 melanoma-bearing mice. Br J Pharmacol. 2017; 174: 139-49. https://doi.org/10.1111/ bph.13662.Maccari, S. et al. Biphasic effects of propranolol on tumour growth in B16F10 melanoma-bearing mice. Br J Pharmacol 174, 139-149, ...
Under optimal conditions of drug dose, light dose, and interval between drug administration and irradiation – the median survival time of C57BL/6 tumor bearing mice was approximately doubled (29 d) compared with tumor bearing control animals (13 d). The life‐...
To prove the role of CD8T cells in immune process, we sorted the CD8T cells from the immunized mice and transferred them to the B16F10 tumor-bearing mice, the result showed that the survival rate was improved. We also observed that in the mice immunized with Luteolin as an adjuvant, the...